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,
,
,
Article History
Received: 26 April 2021
Accepted: 17 October 2022
First Online: 6 December 2022
Competing interests
: All deCODE affiliated authors are employees of deCODE/Amgen. The TIMI Study Group has received institutional research grant support through Brigham and Women’s from Abbott, Amgen, Aralez, AstraZeneca, Bayer HealthCare Pharmaceuticals, BRAHMS, Daiichi-Sankyo, Eisai, GlaxoSmithKline, Intarcia, Janssen, MedImmune, Merck, Novartis, Pfizer, Poxel, Quark Pharmaceuticals, Roche, Takeda, The Medicines Company, and Zora Biosciences. R.C., J.C.H., M.I. and F.M. work at the Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, which receives research grants from industry that are governed by the University of Oxford contracts that protect its independence and has a staff policy of not taking personal payments from industry; further details can be found at ExternalRef removed. A.S.B. reports grants outside of this work from AstraZeneca, Bayer, Biogen, BioMarin, Bioverativ, Merck, Novartis and Sanofi. A.B. and L.A.L. are employees of Regeneron Pharmaceuticals and the spouse of C.J.W. works at Regeneron Pharmaceuticals. J.L.M.B. and A.R. are members of the board of directors, founders and shareholders of Clinical Gene Networks AB that has an invested interest in STARNET. J.D. serves on scientific advisory boards for AstraZeneca, Novartis, and UK Biobank and has received multiple grants from academic, charitable and industry sources outside of the submitted work. J.C.U. has received compensation for consulting from Goldfinch Bio and is an employee of Patch Biosciences. O.G. became a full-time employee of UCB while this manuscript was being drafted. The other authors declare no conflicts of interest.