Chen, Yi Fan http://orcid.org/0000-0002-7757-4462
Ghazala, Maryam
Friedrich, Ryan M. http://orcid.org/0000-0001-6917-9924
Cordova, Brittany A.
Petroze, Frederick N.
Srinivasan, Ramya
Allan, Kevin C.
Yan, David F. http://orcid.org/0000-0003-2919-4796
Sax, Joel L.
Carr, Kelley
Tomchuck, Suzanne L. http://orcid.org/0000-0002-4068-3470
Fedorov, Yuriy http://orcid.org/0000-0001-9513-8341
Huang, Alex Y.
Desai, Amar B.
Adams, Drew J. http://orcid.org/0000-0002-3038-336X
Funding for this research was provided by:
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (AI171104)
Dr. Ralph and Marian Falk Medical Research Trust
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (T32GM007250, T32GM135081, T32GM007250, T32GM007250)
The Harrington Discovery Institute accelerates promising discoveries into medicines for unmet needs
U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (F30HD096784)
Article History
Received: 13 June 2023
Accepted: 22 February 2024
First Online: 25 March 2024
Competing interests
: Y.F.C., R.S., D.F.Y. and D.J.A. are inventors on a provisional patent (63/627,975) filed by Case Western Reserve University on the synthesis of small molecules, their analogs and their derivatives that target XPO1 to suppress T cell activation with minimal cytotoxicity. The other authors declare no competing interests.