Zappasodi, Roberta
Sirard, Cynthia
Li, Yanyun
Budhu, Sadna
Abu-Akeel, Mohsen
Liu, Cailian
Yang, Xia
Zhong, Hong
Newman, Walter
Qi, Jingjing
Wong, Phillip
Schaer, David
Koon, Henry
Velcheti, Vamsidhar
Hellmann, Matthew D.
Postow, Michael A.
Callahan, Margaret K.
Wolchok, Jedd D. http://orcid.org/0000-0001-6718-2222
Merghoub, Taha http://orcid.org/0000-0002-1518-5111
Article History
Received: 14 February 2019
Accepted: 12 March 2019
First Online: 29 April 2019
Competing interests
: R.Z. is inventor on patent applications related to work on GITR, PD-1 and CTLA-4. R.Z. is consultant for Leap Therapeutics. C.S. and W.N. are employed by Leap Therapeutics and report stock option ownership in Leap Therapeutics. P.W. is a consultant for Leap Therapeutics. V.V. reports consultant/advisory roles for Genentech, Bristol Myers Squibb, Merck, AstraZenca, Celgene, Alkermes, Nektar Therapeutics, Reddy labs, Foundation Medicine and Taekeda Oncology, and institutional research grants from Genentech, Bristol Myers Squibb, Merck, Astrazenca, Leap therapeutics, Alkermes and Altor Biosciences. M.D.H. has received research funding from Bristol-Myers Squibb; is paid a consultant to Merck, Bristol-Myers Squibb, AstraZeneca, Genentech/Roche, Janssen, Nektar, Syndax, Mirati, and Shattuck Labs; has received travel support/honoraria from AztraZeneca and BMS; and a patent has been filed by MSK related to the use of tumor mutation burden to predict response to immunotherapy (PCT/US2015/062208), which has received licensing fees from PGDx. M.A.P. is a consultant for Bristol Myers Squibb, Merck, Array BioPharma, Novartis, Incyte, NewLink Genetics and Aduro. M.A.P. reports grants from RGenix, Infinity, Bristol Myers Squibb, Merck, Array BioPharma, AstraZeneca and Novartis, and honoraria from Bristol Myers Squibb and Merck. M.K.C. reports grants from and employment of a family member by Bristol Myers Squibb; personal fees for advisory/consulting role from AstraZeneca/MedImmune, Incyte, Moderna and Merck. T.M. is a consultant for Leap Therapeutics, Immunos Therapeutics and Pfizer, and co-founder of Imvaq therapeutics. T.M. has equity in Imvaq therapeutics. T.M. reports grants from Bristol Myers Squibb, Surface Oncology, Kyn Therapeutics, Infinity Pharmaceuticals, Peregrine Pharmeceuticals, Adaptive Biotechnologies, Leap Therapeutics and Aprea. T.M. is inventor on patent applications related to work on oncolytic viral therapy, alphavirus-based vaccines, neo-antigen modeling, CD40, GITR, OX40, PD-1 and CTLA-4. J.D.W. is a consultant for Adaptive Biotech, Advaxis, Amgen, Apricity, Array BioPharma, Ascentage Pharma, Astellas, Bayer, Beigene, Bristol Myers Squibb, Celgene, Chugai, Elucida, Eli Lilly, F Star, Genentech, Imvaq, Janssen, Kleo Pharma, Linneaus, MedImmune, Merck Pharmaceuticals, Neon Therapuetics, Ono, Polaris Pharma, Polynoma, Psioxus, Puretech, Recepta, Trieza, Sellas Life Sciences, Serametrix, Surface Oncology and Syndax. J.D.W. reports grants from Bristol Myers Squibb, Medimmune, Merck Pharmaceuticals and Genentech. J.D.W. has equity in Potenza Therapeutics, Tizona Pharmaceuticals, Adaptive Biotechnologies, Elucida, Imvaq, Beigene, Trieza and Linneaus. J.D.W. is inventor on patent applications related to work on DNA vaccines in companion animals with cancer, assays for suppressive myeloid cells in blood, oncolytic viral therapy, alphavirus-based vaccines, neo-antigen modeling, CD40, GITR, OX40, PD-1 and CTLA-4. The other authors declare no competing interests.