Nakamura, Yoshiaki
Okamoto, Wataru
Kato, Takeshi
Esaki, Taito
Kato, Ken http://orcid.org/0000-0002-1733-5072
Komatsu, Yoshito http://orcid.org/0000-0002-1570-6802
Yuki, Satoshi
Masuishi, Toshiki
Nishina, Tomohiro
Ebi, Hiromichi http://orcid.org/0000-0003-3155-7576
Sawada, Kentaro
Taniguchi, Hiroya
Fuse, Nozomu
Nomura, Shogo
Fukui, Makoto
Matsuda, Seiko
Sakamoto, Yasutoshi
Uchigata, Hiroshi
Kitajima, Kana
Kuramoto, Naomi
Asakawa, Takashi
Olsen, Steve
Odegaard, Justin I.
Sato, Akihiro
Fujii, Satoshi
Ohtsu, Atsushi
Yoshino, Takayuki http://orcid.org/0000-0002-0489-4756
Funding for this research was provided by:
SCRUM-Japan Funds
Japan Agency for Medical Research and Development (19ck0106445h0002, 16lk0201054h0001, 16lk0201056s0001)
National Cancer Center Research and Development Fund
Article History
Received: 24 June 2021
Accepted: 23 September 2021
First Online: 11 November 2021
Competing interests
: K.S., N.F., M.F., S.M., Y.S., H.U., K. Kitajima and N.K. have nothing to disclose. Y.N. reports grants from Taiho Pharmaceutical, grants from Chugai Pharmaceutical, grants from Guardant Health and grants from Genomedia, all outside of the submitted work. W.O. reports grants from the Japan Agency for Medical Research and Development, non-financial support from Chugai, non-financial support from Guardant Health and non-financial support from Abbott, during the conduct of the study. W.O. also reports personal fees from Chugai, personal fees from Ono, personal fees from Bristol Myers Squibb, personal fees from Yakult Honsha, personal fees from Thermo Fisher Scientific and grants from Janssen, all outside of the submitted work. T.K. reports personal fees from Ono, grants and personal fees from Chugai, grants and personal fees from Takeda, personal fees from Taiho, personal fees from Bayer Yakuhin Japan and personal fees from Boehringer Ingelheim, all outside of the submitted work. T.E. reports grants from MSD, grants from Novartis, grants from Dainippon Sumitomo, grants and personal fees from Ono, grants and personal fees from Daiichi Sankyo, grants from Astellas, grants from AstellasAmgenBiopharma, grants from BeiGene, grants from Pierre Fabre Medicament, grants from Ignyta, grants from Array BioPharma, grants and personal fees from Merck Serono, grants and personal fees from Bayer, grants from Eisai, grants and personal fees from Eli Lilly, grants from Nihonkayaku, personal fees from Taiho, personal fees from Chugai, personal fees from Sanofi and personal fees from Takeda, all outside of the submitted work. K. Kato reports other from Ono, other from MSD, other from Beigene, other from Shionogi, other from Oncolysi Biopharma, other from AstraZeneca, other from Bayer and other from Chugai, all outside of the submitted work. Y.K. reports grants from A2 Healthcare, grants and personal fees from Bayer Yakuhin, grants and personal fees from Daiichi Sankyo, grants from Dainippon Sumitomo, grants from Eisai, grants from EPâCRSU, grants from EPS, grants and personal fees from Eli Lilly Japan, grants from Linical, grants and personal fees from MSD, grants from NanoCarrier, grants from QuintilesIMS, grants from Sysmex, grants and personal fees from Taiho, grants and personal fees from Kyowa Kirin, personal fees from Bristol Myers Squibb, personal fees from Chugai, personal fees from EA Pharma, grants and personal fees from Ono, grants and personal fees from Sanofi, personal fees from Takeda, personal fees from Merck Biopharma, personal fees from Nipro, personal fees from Pfizer Japan, personal fees from Sawai, personal fees from Shiseido, grants and personal fees from Yakult Honsha, grants from Astellas, grants from Incyte, grants from IQVIA, grants from Syneos Health Clinical, personal fees from Asahi Kasei, personal fees from Mitsubishi Tanabe, personal fees from Merck Biopharma, personal fees from Shire Japan, personal fees from Nippon Kayaku, personal fees from Otsuka Pharmaceutical Factory and personal fees from Novartis, all outside of the submitted work. S.Y. reports personal fees from Chugai, personal fees from Eli Lilly, personal fees from Takeda, personal fees from Bayer Yakuhin, personal fees from Bristol Myers Squibb, personal fees from Taiho, personal fees from MSD, personal fees from Ono, personal fees from Medical & Biological Laboratories, personal fees from Yakult Honsha, personal fees from Merck Biopharma and personal fees from Sanofi, all outside of the submitted work. T.M. reports personal fees from Takeda, personal fees from Chugai, personal fees from Merck, personal fees from Taiho, personal fees from Bayer, personal fees from Eli Lilly Japan, personal fees from Yakult Honsha, personal fees from Sanofi, grants from MSD, grants from Daiichi Sankyo and grants from Ono, all outside of the submitted work. T.N. reports grants from Daiichi Sankyo, during the conduct of the study; grants and personal fees from Bristol Myers Squibb, grants and personal fees from Ono, grants and personal fees from Taiho, grants and personal fees from Chugai, grants and personal fees from Eli Lilly, grants from Dainippon Sumitomo and grants from MSD, all outside of the submitted work. H.E. reports honoraria from Taiho, Chugai, AstraZeneca and Takeda, all outside of the submitted work. H.T. reports personal fees from Bayer, personal fees from Sanofi, grants and personal fees from Takeda, personal fees from Chugai, grants and personal fees from Taiho, personal fees from Eli Lilly, personal fees from Merck Biopharma, grants and personal fees from Daiichi Sankyo, personal fees from Bristol Myers Squibb, personal fees from MBL, personal fees from MSD, personal fees from Novartis and personal fees from Ono, all outside of the submitted work. S.N. reports personal fees from AstraZeneca, personal fees from Chugai, personal fees from Pfizer and grants from Amgen, all outside of the submitted work. T.A. reports personal fees from Chugai, during the conduct of the study, and personal fees from Chugai, all outside of the submitted work. S.O. reports other from Guardant Health AMEA, during the conduct of the study, other from AstraZeneca and other from Guardant Health, all outside of the submitted work. J.I.O. is an employee of Guardant Health. A.S. reports grants from the Japanese Government, during the conduct of the study; grants from MSD, grants from Eisai, grants from Ono, grants from Taiho, grants from Takeda, grants from Dainippon Sumitomo, grants from Rakuten Medical, grants from Oncolys BioPhama, grants from AstraZeneca and grants from Pentax, all outside of the submitted work. S.F. reports grants from Daiichi Sankyo, outside of the submitted work. A.O. reports grants and personal fees from Bristol Myers Squibb, personal fees from Ono, personal fees from Taiho, personal fees from Chugai, personal fees from Eisai and personal fees from Merck Serono, all during the conduct of the study. T.Y. reports grants from Taiho, grants from Sumitomo Dainippon, grants from Ono, grants from Chugai, grants from Amgen, grants from Parexel, grants from MSD, grants from Daiichi Sankyo and grants from Sanofi, all outside of the submitted work.