Patel, Aniruddh P.
Wang, Minxian http://orcid.org/0000-0002-3753-508X
Ruan, Yunfeng
Koyama, Satoshi
Clarke, Shoa L. http://orcid.org/0000-0002-6592-1172
Yang, Xiong
Tcheandjieu, Catherine http://orcid.org/0000-0001-9559-4339
Agrawal, Saaket
Fahed, Akl C.
Ellinor, Patrick T. http://orcid.org/0000-0002-2067-0533
Tsao, Philip S. http://orcid.org/0000-0001-7274-9318
Sun, Yan V. http://orcid.org/0000-0002-2838-1824
Cho, Kelly
Wilson, Peter W. F.
Assimes, Themistocles L. http://orcid.org/0000-0003-2349-0009
van Heel, David A. http://orcid.org/0000-0002-0637-2265
Butterworth, Adam S. http://orcid.org/0000-0002-6915-9015
Aragam, Krishna G.
Natarajan, Pradeep http://orcid.org/0000-0001-8402-7435
Khera, Amit V. http://orcid.org/0000-0001-6535-5839
,
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (1K08HG010155, 1U01HG011719, 1U01HG011719, 1U01HG011719)
Massachusetts General Hospital
Broad Institute
Harvard Catalyst
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (1K08HL161448, 1RO1HL092577, 1R01HL157635, 1R01HL157635, 1K08HL153937, R01HL1427, R01HL148565, R01HL148050)
American Heart Association (18SFRN34110082, 17IFUNP3384001)
U.S. Department of Veterans Affairs (01BX003362, I01-BX004821, I01-BX004821)
Article History
Received: 26 August 2022
Accepted: 30 May 2023
First Online: 6 July 2023
Competing interests
: S.A. has served as a scientific advisor to Third Rock Ventures. A.C.F. is a co-founder of Goodpath and reports a grant from Abbott Vascular. P.T.E. receives sponsored research support from Bayer AG and IBM Research; he has also served on advisory boards or consulted for Bayer AG, MyoKardia and Novartis. A.S.B. reports institutional grants from AstraZeneca, Bayer, Biogen, BioMarin, Bioverativ, Novartis, Regeneron and Sanofi. P.N. reports research grants from Allelica, Apple, Amgen, Boston Scientific, Genentech/Roche and Novartis, personal fees from Allelica, Apple, AstraZeneca, Blackstone Life Sciences, Foresite Labs, Genentech/Roche, GV, HeartFlow, Magnet Biomedicine and Novartis, scientific advisory board membership of Esperion Therapeutics, Preciseli and TenSixteen Bio, scientific co-founder of TenSixteen Bio, equity in Preciseli and TenSixteen Bio, and spousal employment at Vertex Pharmaceuticals, all unrelated to the present work. A.V.K. is an employee of Verve Therapeutics; has served as a scientific advisor to Amgen, Novartis, Silence Therapeutics, Korro Bio, Veritas International, Color Health, Third Rock Ventures, Illumina, Ambry and Foresite Labs; holds equity in Verve Therapeutics, Color Health and Foresite Labs; and is listed as a co-inventor on patent applications related to assessment and mitigation of risk associated with perturbations in body fat distribution. The remaining authors declare no competing interests.