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A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects

Crossref DOI link: https://doi.org/10.1038/s41592-020-0832-x

Published Online: 2020-05-18

Published Print: 2020-06

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zuo, Erwei https://orcid.org/0000-0001-8259-0275
Sun, Yidi https://orcid.org/0000-0002-4191-2917
Yuan, Tanglong https://orcid.org/0000-0003-4670-2625
He, Bingbing https://orcid.org/0000-0002-9790-8087
Zhou, Changyang https://orcid.org/0000-0002-3012-1001
Ying, Wenqin https://orcid.org/0000-0001-5711-5923
Liu, Jing https://orcid.org/0000-0002-4036-789X
Wei, Wu https://orcid.org/0000-0001-5643-8739
Zeng, Rong

Li, Yixue https://orcid.org/0000-0002-1198-7176
Yang, Hui https://orcid.org/0000-0003-3590-722X
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (91957122, 31922048)
License Information

Text and Data Mining valid from 2020-05-18

Version of Record valid from 2020-05-18
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Article History

Received: 18 January 2020

Accepted: 13 April 2020

First Online: 18 May 2020

Competing interests

: The authors disclose a patent application relating to aspects of this work (engineered base editors).