Leng, Kun http://orcid.org/0000-0001-9931-1375
Rose, Indigo V. L. http://orcid.org/0000-0003-0491-1269
Kim, Hyosung
Xia, Wenlong
Romero-Fernandez, Wilber
Rooney, Brendan
Koontz, Mark
Li, Emmy
Ao, Yan
Wang, Shinong
Krawczyk, Mitchell
TCW, Julia
Goate, Alison http://orcid.org/0000-0002-0576-2472
Zhang, Ye http://orcid.org/0000-0002-1546-5930
Ullian, Erik M. http://orcid.org/0000-0003-2077-8584
Sofroniew, Michael V. http://orcid.org/0000-0001-6075-0178
Fancy, Stephen P. J. http://orcid.org/0000-0002-2818-8258
Schrag, Matthew S.
Lippmann, Ethan S. http://orcid.org/0000-0001-5703-5747
Kampmann, Martin http://orcid.org/0000-0002-3819-7019
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute on Aging (F30 AG066418, K01 AG062683, R03 AG063157)
California Institute for Regenerative Medicine (EDUC4-12812)
U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (T32 NS115706, R01 NS09755, P01 NS083513, R21 NS119954)
New York Stem Cell Foundation (Druckenmiller Fellowship)
U.S. Department of Health & Human Services | NIH | National Eye Institute (P30 EY02162-39)
National Multiple Sclerosis Society (Harry Weaver Neuroscience Scholarship)
Chan Zuckerberg Initiative Ben Barres Early Career Acceleration Award
Article History
Received: 23 August 2021
Accepted: 7 September 2022
First Online: 27 October 2022
Competing interests
: M. Kampmann is an inventor on US Patent 11,254,933 related to CRISPRi and CRISPRa screening, serves on the scientific advisory boards of Engine Biosciences, Casma Therapeutics, Cajal Neuroscience and Alector and is an advisor to Modulo Bio and Recursion Therapeutics. J.T. co-founded Asmos Therapeutics, LLC, serves on the scientific advisory board of NeuCyte, Inc. and has consulted for FIND Genomics Inc., CareCureSystems Corporation, TheWell Biosciences Inc. and Aleta Neuroscience, LLC. A.G. serves on the scientific advisory board for Genentech and is a consultant to Muna Therapeutics. None of the other authors declare competing interests.