Koike, Naoyoshi http://orcid.org/0000-0003-1952-0252
Kota, Ryuichi
Naito, Yoshiko
Hayakawa, Noriyo
Matsuura, Tomomi
Hishiki, Takako
Onishi, Nobuyuki
Fukada, Junichi
Suematsu, Makoto http://orcid.org/0000-0002-7165-6336
Shigematsu, Naoyuki
Saya, Hideyuki
Sampetrean, Oltea http://orcid.org/0000-0001-5783-1049
Funding for this research was provided by:
MEXT | Japan Science and Technology Agency (16K07124, 19K07671, 18K15602)
Article History
Received: 12 November 2019
Accepted: 20 July 2020
First Online: 17 August 2020
Competing interests
: H.S. has received commercial research grants from POLA Pharma Inc. and Nihon Noyaku Co. Ltd. O.S. has received research support from Nihon Noyaku Co. Ltd. The findings of this study are the subject of a Japanese patent application as follows: Applicants: Keio University and POLA Pharma Inc. Inventors: H.S., O.S., N.K., and N. Kubota. Application no.: PCT/JP2018/036792. Status: international publication. Specific aspects of the study covered in the application: radiosensitizing effect of doranidazole on GSCs as well as its effects on mitochondrial complexes and ROS. Doranidazole used in this study was provided by POLA Pharma Inc. All other authors declare no competing interests.