Zhang, Xiao-lei
Hollander, Callie M. http://orcid.org/0000-0002-3434-0068
Khan, Mohammad Yasir
D’silva, Melinee
Ma, Haoqin http://orcid.org/0000-0001-8912-5528
Yang, Xinyuan
Bai, Robin
Keeter, Coles K.
Galkina, Elena V.
Nadler, Jerry L.
Stanton, Patric K. http://orcid.org/0000-0002-2294-0613
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (HL142129-04S1)
Article History
Received: 4 July 2022
Accepted: 30 August 2023
First Online: 2 October 2023
Competing interests
: The authors declare the following competing interests: U.S. provisional patent: “USE OF STAT4 INHIBITORS FOR PREVENTION AND TREATMENT OF ALZHEIMER’S DISEASE”. Patent Applicant: New York Medical College. Name of Inventors: Jerry L. Nadler, Patric K. Stanton. Application Number: 20230233595, Status: Published, Aspect of manuscript covered in the provisional patent: The observations in this manuscript, that deficiency in Stat4 protects long-term synaptic plasticity from the effects of a high-fat, high-cholesterol Western diet, support the hypothesis of this provisional patent that inhibitors of Stat4 have the potential to slow or prevent the development of Alzheimer’s disease, which is also promoted by a Western diet, and also involves activation of neuroinflammatory pathways.