Farkas, Emese http://orcid.org/0009-0008-9331-9200
Sátorhelyi, Péter
Szakács, Zoltán http://orcid.org/0000-0001-6557-4409
Dékány, Miklós http://orcid.org/0000-0001-8032-2998
Vaskó, Dorottya
Hornyánszky, Gábor http://orcid.org/0000-0001-7895-9711
Poppe, László http://orcid.org/0000-0002-8358-1378
Éles, János http://orcid.org/0000-0001-9185-1123
Article History
Received: 2 November 2023
Accepted: 13 March 2024
First Online: 18 April 2024
Competing interests
: E.F., Z.S., M.D., and J.É. are employees of Richter Gedeon Plc.—developer of the atypical antipsychotic drug cariprazine. The transaminase-based dynamic isomerization concept revealed by this study comprised the basis of a patent application related to industrial synthesis of cariprazine [Farkas, E.; Poppe, L.; Hornyánszky, G.; Incze, D.J.; Éles, J.; Sánta-Bell, E.; Molnár, Z.K.; Szemes, J.; Schneider, A.; Csuka, P. (Gedeon Richter Plc.-BME) Process to produce (1<i>r</i>,4<i>r</i>)-4-substituted cyclohexane-1-amines. <i>WIPO Int. Appl</i>. WO 2023/042081 A1 (2023)<sup>55</sup>. All other authors declare no competing interests.