Funding for this research was provided by:
Royal Society (RS/R1/180086)
Wellcome (205200/Z/16/Z, 101506/Z/13/Z, 210794/Z/18/Z)
Academy of Medical Sciences (HOP001/1029)
Received: 14 May 2019
Accepted: 25 November 2019
First Online: 13 January 2020
: M.E. received personal fees from Prudential, Scor and Third Bridge, and a charitable grant from the AstraZeneca Young Health Programme, outside the submitted work. The other authors declare no competing interests.