Pan, Xiaoxi
AbdulJabbar, Khalid http://orcid.org/0000-0002-4411-4435
Coelho-Lima, Jose
Grapa, Anca-Ioana
Zhang, Hanyun
Cheung, Alvin Ho Kwan http://orcid.org/0000-0002-3913-8117
Baena, Juvenal http://orcid.org/0000-0002-8027-9149
Karasaki, Takahiro http://orcid.org/0000-0001-6863-2360
Wilson, Claire Rachel http://orcid.org/0000-0002-6401-2014
Sereno, Marco http://orcid.org/0000-0003-4573-9303
Veeriah, Selvaraju
Aitken, Sarah J. http://orcid.org/0000-0002-1897-4140
Hackshaw, Allan http://orcid.org/0000-0002-5570-5070
Nicholson, Andrew G.
Jamal-Hanjani, Mariam http://orcid.org/0000-0003-1212-1259
Le Quesne, John
Janes, Sam M.
Hacker, Anne-Marie
Sharp, Abigail
Smith, Sean
Dhanda, Harjot Kaur
Chan, Kitty
Pilotti, Camilla
Leslie, Rachel
Chuter, David
MacKenzie, Mairead
Chee, Serena
Alzetani, Aiman
Lim, Eric
De Sousa, Paulo
Jordan, Simon
Rice, Alexandra
Raubenheimer, Hilgardt
Bhayani, Harshil
Ambrose, Lyn
Devaraj, Anand
Chavan, Hema
Begum, Sofina
Buderi, Silviu I.
Kaniu, Daniel
Malima, Mpho
Booth, Sarah
Fernandes, Nadia
Shah, Pratibha
Proli, Chiara
Hewish, Madeleine
Danson, Sarah
Shackcloth, Michael J.
Robinson, Lily
Russell, Peter
Blyth, Kevin G.
Kidd, Andrew
Kirk, Alan
Asif, Mo
Bilancia, Rocco
Kostoulas, Nikos
Thomas, Mathew
Dick, Craig
Lester, Jason F.
Bajaj, Amrita
Nakas, Apostolos
Sodha-Ramdeen, Azmina
Tufail, Mohamad
Scotland, Molly
Boyles, Rebecca
Rathinam, Sridhar
Fennell, Dean A.
Wilson, Claire
Marrone, Domenic
Dulloo, Sean
Matharu, Gurdeep
Shaw, Jacqui A.
Riley, Joan
Primrose, Lindsay
Boleti, Ekaterini
Cheyne, Heather
Khalil, Mohammed
Richardson, Shirley
Cruickshank, Tracey
Price, Gillian
Kerr, Keith M.
Benafif, Sarah
Papadatos-Pastos, Dionysis
Wilson, James
Ahmad, Tanya
French, Jack
Gilbert, Kayleigh
Naidu, Babu
Patel, Akshay J.
Osman, Aya
Lacson, Christer
Langman, Gerald
Shackleford, Helen
Djearaman, Madava
Kadiri, Salma
Middleton, Gary
Leek, Angela
Hodgkinson, Jack Davies
Totten, Nicola
Montero, Angeles
Smith, Elaine
Fontaine, Eustace
Granato, Felice
Novasio, Juliette
Rammohan, Kendadai
Joseph, Leena
Bishop, Paul
Shah, Rajesh
Moss, Stuart
Joshi, Vijay
Crosbie, Philip
Paiva-Correia, Antonio
Chaturvedi, Anshuman
Priest, Lynsey
Oliveira, Pedro
Gomes, Fabio
Brown, Kate
Carter, Mathew
Lindsay, Colin R.
Blackhall, Fiona H.
Krebs, Matthew G.
Summers, Yvonne
Clipson, Alexandra
Tugwood, Jonathan
Kerr, Alastair
Rothwell, Dominic G.
Dive, Caroline
Aerts, Hugo J. W. L.
Schwarz, Roland F.
Kaufmann, Tom L.
Van Loo, Peter
Wilson, Gareth A.
Rosenthal, Rachel
Rowan, Andrew
Bailey, Chris
Lee, Claudia
Colliver, Emma
Enfield, Katey S. S.
Hill, Mark S.
Angelova, Mihaela
Pich, Oriol
Leung, Michelle
Frankell, Alexander M.
Hiley, Crispin T.
Lim, Emilia L.
Zhai, Haoran
Bakir, Maise Al
Birkbak, Nicolai J.
Lucas, Olivia
Huebner, Ariana
Puttick, Clare
Grigoriadis, Kristiana
Dietzen, Michelle
Biswas, Dhruva
Athanasopoulou, Foteini
Ward, Sophia
Demeulemeester, Jonas
Castignani, Carla
Cadieux, Elizabeth Larose
Kisistok, Judit
Sokac, Mateo
Szallasi, Zoltan
Diossy, Miklos
Salgado, Roberto
Stewart, Aengus
Magness, Alastair
Weeden, Clare E.
Levi, Dina
Grönroos, Eva
Noorani, Imran
Goldman, Jacki
Escudero, Mickael
Hobson, Philip
Vendramin, Roberto
Boeing, Stefan
Denner, Tamara
Barbè, Vittorio
Lu, Wei-Ting
Hill, William
Naito, Yutaka
Ramsden, Zoe
Kassiotis, George
Dwornik, Angela
Karamani, Angeliki
Chain, Benny
Pearce, David R.
Karagianni, Despoina
Gálvez-Cancino, Felip
Stavrou, Georgia
Mastrokalos, Gerasimos
Lowe, Helen L.
Matos, Ignacio Garcia
Reading, James L.
Hartley, John A.
Selvaraju, Kayalvizhi
Chen, Kezhong
Ensell, Leah
Shah, Mansi
Litovchenko, Maria
Chervova, Olga
Pawlik, Piotr
Hynds, Robert E.
Gamble, Samuel
Ung, Seng Kuong Anakin
Bola, Supreet Kaur
Spanswick, Victoria
Wu, Yin
Al-Sawaf, Othman
Jones, Thomas Patrick
Beck, Stephan
Tanic, Miljana
Marafioti, Teresa
Borg, Elaine
Falzon, Mary
Khiroya, Reena
Toncheva, Antonia
Abbosh, Christopher
Richard, Corentin
Naceur-Lombardelli, Cristina
Gimeno-Valiente, Francisco
Thakkar, Krupa
Sunderland, Mariana Werner
Sivakumar, Monica
Kanu, Nnennaya
Prymas, Paulina
Saghafinia, Sadegh
Vanloo, Sharon
Lam, Jie Min
Liu, Wing Kin
Bunkum, Abigail
Hessey, Sonya
Zaccaria, Simone
Martínez-Ruiz, Carlos
Black, James R. M.
Thol, Kerstin
Bentham, Robert
Litchfield, Kevin
McGranahan, Nicholas
Quezada, Sergio A.
Forster, Martin D.
Lee, Siow Ming
Herrero, Javier
Nye, Emma
Stone, Richard Kevin
Nicod, Jerome
Rane, Jayant K.
Peggs, Karl S.
Ng, Kevin W.
Dijkstra, Krijn
Huska, Matthew R.
Hoogenboom, Emilie Martinoni
Monk, Fleur
Holding, James W.
Choudhary, Junaid
Bhakhri, Kunal
Scarci, Marco
Gorman, Pat
Stephens, Robert C. M.
Wong, Yien Ning Sophia
Kaplar, Zoltan
Bandula, Steve
Watkins, Thomas B. K.
Veiga, Catarina
Royle, Gary
Collins-Fekete, Charles-Antoine
Fraioli, Francesco
Ashford, Paul
Procter, Alexander James
Ahmed, Asia
Taylor, Magali N.
Nair, Arjun
Lawrence, David
Patrini, Davide
Navani, Neal
Thakrar, Ricky M.
Swanton, Charles http://orcid.org/0000-0002-4299-3018
Yuan, Yinyin
Le Quesne, John http://orcid.org/0000-0003-3552-7446
Moore, David A. http://orcid.org/0000-0002-6296-1312
,
Funding for this research was provided by:
Cancer Research UK (C45982/A21808, CC2041, C11496/A17786)
Wellcome Trust (CC2041)
UK Medical Research Council
Article History
Received: 6 December 2022
Accepted: 21 November 2023
First Online: 10 January 2024
Competing interests
: S.V. is a coinventor to a patent of methods for detecting molecules in a sample (patent no. 10578620). A.H. has received fees from Abbvie, Almirall, Boehringer Ingelheim, Clovis Oncology, Ipsen, Takeda Pharmaceuticals, AstraZeneca, Daiichi Sankyo, Merck Serono, Merck/MSD, UCB, Kyowa Kirin, Servier, Sobi, Pfizer and Roche for delivering general education and training in clinical trials; has received fees for member of independent data monitoring committees for Roche-sponsored clinical trials and academic projects on real-world evidence or tumor-agnostic therapies coordinated by Roche; he has been paid honoraria for speaking at Roche-funded conferences (on real-world data); he has an academic collaboration with Navio and is an unpaid member of their advisory board; he is an investigator for an academic study (SUMMIT) sponsored by UCL, which is funded by GRAIL; he has received one honorarium for an advisory board meeting for GRAIL; he has received a consulting fee from Evidera (for one GRAIL-initiated project); and he has previously owned shares in Illumina and Thermo Fisher Scientific (sold in 2020); he is on the scientific advisory board for Adela Bio and has received no payments or honoraria for this, although he has share options available. A.G.N. reports personal fees from Merck, Boehringer Ingelheim, Novartis, AstraZeneca, Bristol Myers Squibb, Roche, Abbvie, Oncologica, Uptodate, the European Society of Oncology, Takeda Pharmaceuticals, Sanofi and Liberium, as well as personal fees and grants from Pfizer. M.J-H. is a Cancer Research UK Career Establishment Awardee and has received funding from Cancer Research UK, the International Association for the Study of Lung Cancer and International Lung Cancer Foundation, the Lung Cancer Research Foundation, the Rosetrees Trust, UK and Ireland Neuroendocrine Tumour Society, the National Institute for Health Research (NIHR) and the NIHR UCLH Biomedical Research Centre. M.J-H. has consulted for, and is a member of, the Achilles Therapeutics Scientific advisory board and steering committee, has received speaker honoraria from Pfizer, Astex Pharmaceuticals and Oslo Cancer Cluster, and holds a patent (no. PCT/US2017/028013) relating to methods for lung cancer detection. C.S. acknowledges grant support from AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, Pfizer, Roche-Ventana, Invitae (previously Archer Dx, collaboration in minimal residual disease sequencing technologies) and Ono Pharmaceutical. He is an AstraZeneca advisory board member and chief investigator for the AZ MeRmaiD 1 and 2 clinical trials; he is also co-chief investigator of the NHS Galleri trial funded by GRAIL and a paid member of GRAIL’s scientific advisory board. He receives consultant fees from Achilles Therapeutics (scientific advisory board member), Bicycle Therapeutics (scientific advisory board), Genentech, Medicxi, Roche Innovation Centre-Shanghai, Metabomed (until July 2022) and the Sarah Cannon Research Institute. C.S. has received honoraria from Amgen, AstraZeneca, Pfizer, Novartis, GlaxoSmithKline, MSD, Bristol Myers Squibb, Illumina and Roche-Ventana. C.S. had stock options in Apogen Biotechnologies and GRAIL until June 2021; he currently has stock options in Epic Bioscience, Bicycle Therapeutics; he has stock options and is a cofounder of Achilles Therapeutics. C.S. holds patents relating to assay technology to detect tumor recurrence (no. PCT/GB2017/053289), target neoantigens (no. PCT/EP2016/059401), identify patent response to immune checkpoint blockade (no. PCT/EP2016/071471), determine HLA loss of heterozygosity (no. PCT/GB2018/052004), predict survival rates of patients with cancer (no. PCT/GB2020/050221) and identify patients who respond to cancer treatment (no. PCT/GB2018/051912), as well as a US patent related to detecting tumor mutations (no. PCT/US2017/28013) and methods for lung cancer detection (no. US20190106751A1), and both European and US patents related to identifying insertion and deletion mutation targets (no. PCT/GB2018/051892). Y.Y. has received speaker’s bureau honoraria from Roche and consulted for Merck. D.A.M. reports speaker fees from Eli Lilly, AstraZeneca and Takeda Pharmaceuticals, consultancy fees from AstraZeneca, Thermo Fisher Scientific, Takeda Pharmaceuticals, Amgen, Janssen, MIM Software, Bristol Myers Squibb and Eli Lilly, and has received educational support from Takeda Pharmaceuticals and Amgen. All other authors declare no competing interests.