de Vries, Paul S. http://orcid.org/0000-0003-0964-0111
Conomos, Matthew P. http://orcid.org/0000-0001-9744-0851
Singh, Kuldeep
Nicholson, Christopher J.
Jain, Deepti
Hasbani, Natalie R.
Jiang, Wanlin http://orcid.org/0000-0001-9631-2540
Lee, Sujin
Lino Cardenas, Christian L. http://orcid.org/0000-0001-5491-4375
Lutz, Sharon M.
Wong, Doris
Guo, Xiuqing http://orcid.org/0000-0002-5264-5068
Yao, Jie
Young, Erica P. http://orcid.org/0000-0002-3671-211X
Tcheandjieu, Catherine http://orcid.org/0000-0001-9559-4339
Hilliard, Austin T. http://orcid.org/0000-0002-1289-4377
Bis, Joshua C. http://orcid.org/0000-0002-3409-1110
Bielak, Lawrence F. http://orcid.org/0000-0002-3443-8030
Brown, Michael R.
Musharoff, Shaila
Clarke, Shoa L. http://orcid.org/0000-0002-6592-1172
Terry, James G.
Palmer, Nicholette D. http://orcid.org/0000-0001-8883-2511
Yanek, Lisa R. http://orcid.org/0000-0001-7117-1075
Xu, Huichun http://orcid.org/0000-0001-8118-9607
Heard-Costa, Nancy http://orcid.org/0000-0001-9730-0306
Wessel, Jennifer
Selvaraj, Margaret Sunitha
Li, Rebecca H.
Sun, Xiao http://orcid.org/0000-0001-8802-2957
Turner, Adam W.
Stilp, Adrienne M. http://orcid.org/0000-0002-3910-0776
Khan, Alyna
Newman, Anne B.
Rasheed, Asif
Freedman, Barry I. http://orcid.org/0000-0003-0275-5530
Kral, Brian G. http://orcid.org/0000-0001-9493-2084
McHugh, Caitlin P.
Hodonsky, Chani
Saleheen, Danish http://orcid.org/0000-0001-6193-020X
Herrington, David M.
Jacobs, David R. Jr http://orcid.org/0000-0002-7232-0543
Nickerson, Deborah A.
Boerwinkle, Eric
Wang, Fei Fei
Heiss, Gerardo
Jun, Goo
Kinney, Greg L. http://orcid.org/0000-0002-5218-4986
Sigurslid, Haakon H.
Doddapaneni, HarshaVardhan http://orcid.org/0000-0002-2433-633X
Hall, Ira M. http://orcid.org/0000-0003-4442-6655
Bensenor, Isabela M.
Broome, Jai http://orcid.org/0000-0001-7638-0749
Crapo, James D.
Wilson, James G.
Smith, Jennifer A. http://orcid.org/0000-0002-3575-5468
Blangero, John http://orcid.org/0000-0001-6250-5723
Vargas, Jose D.
Mosquera, Jose Verdezoto
Smith, Joshua D.
Viaud-Martinez, Karine A. http://orcid.org/0009-0001-0877-1358
Ryan, Kathleen A. http://orcid.org/0000-0003-1158-8455
Young, Kendra A. http://orcid.org/0000-0002-8664-7635
Taylor, Kent D.
Lange, Leslie A.
Emery, Leslie S.
Bittencourt, Marcio S.
Budoff, Matthew J. http://orcid.org/0000-0002-9616-1946
Montasser, May E. http://orcid.org/0000-0002-9558-5456
Yu, Miao
Mahaney, Michael C.
Mahamdeh, Mohammed S. http://orcid.org/0000-0003-3985-6992
Fornage, Myriam http://orcid.org/0000-0003-0677-8158
Franceschini, Nora http://orcid.org/0009-0001-8346-3662
Lotufo, Paulo A.
Natarajan, Pradeep http://orcid.org/0000-0001-8402-7435
Wong, Quenna
Mathias, Rasika A. http://orcid.org/0000-0002-2282-9042
Gibbs, Richard A.
Do, Ron http://orcid.org/0000-0002-3144-3627
Mehran, Roxana http://orcid.org/0000-0002-5546-262X
Tracy, Russell P. http://orcid.org/0000-0002-0080-2420
Kim, Ryan W.
Nelson, Sarah C. http://orcid.org/0000-0002-2109-6465
Damrauer, Scott M. http://orcid.org/0000-0001-8009-1632
Kardia, Sharon L. R.
Rich, Stephen S. http://orcid.org/0000-0003-3872-7793
Fuster, Valentin
Napolioni, Valerio http://orcid.org/0000-0002-4378-6838
Zhao, Wei http://orcid.org/0000-0001-7388-0692
Tian, Wenjie
Yin, Xianyong http://orcid.org/0000-0001-6454-2384
Min, Yuan-I http://orcid.org/0000-0003-2470-0004
Manning, Alisa K.
Peloso, Gina http://orcid.org/0000-0002-5355-8636
Kelly, Tanika N.
O’Donnell, Christopher J. http://orcid.org/0000-0002-2667-8624
Morrison, Alanna C. http://orcid.org/0000-0001-6381-4296
Curran, Joanne E. http://orcid.org/0000-0002-6898-155X
Zapol, Warren M.
Bowden, Donald W.
Becker, Lewis C.
Correa, Adolfo http://orcid.org/0000-0002-9501-600X
Mitchell, Braxton D. http://orcid.org/0000-0003-4920-4744
Psaty, Bruce M. http://orcid.org/0000-0002-7278-2190
Carr, John Jeffrey http://orcid.org/0000-0002-4398-8237
Pereira, Alexandre C. http://orcid.org/0000-0002-7782-5540
Assimes, Themistocles L. http://orcid.org/0000-0003-2349-0009
Stitziel, Nathan O. http://orcid.org/0000-0002-4963-8211
Hokanson, John E.
Laurie, Cecelia A. http://orcid.org/0000-0001-6569-2501
Rotter, Jerome I. http://orcid.org/0000-0001-7191-1723
Vasan, Ramachandran S. http://orcid.org/0000-0001-7357-5970
Post, Wendy S.
Peyser, Patricia A. http://orcid.org/0000-0002-9717-8459
Miller, Clint L. http://orcid.org/0000-0003-4276-3607
Malhotra, Rajeev http://orcid.org/0000-0003-0120-4630
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (R01HL146860, R01 HL162928, U01HL137162, R01HL146860, R01HL146860, R01HL146860, R01HL146860, R01HL146860, R01HL146860, R01HL146860, R01HL146860, R01HL146860, R01HL146860, R01HL142809, R01HL159514, R01HL162928, R01HL146860, R01HL146860, K01HL164687, R01HL120393, R01HL142711, R01HL142711, R01HL142711)
American Heart Association (18CDA34110116, 18CDA34110116, 18TPA34230025)
Article History
Received: 13 April 2022
Accepted: 25 October 2023
First Online: 4 December 2023
Competing interests
: B.P.M. serves on the Steering Committee of the Yale Open Data Access Project, funded by Johnson & Johnson. L.S.E. is now an employee of Celgene/Bristol Myers Squibb. Celgene/Bristol Myers Squibb had no role in the funding, design, conduct or interpretation of this study. N.O.S. has received research funding from Regeneron Pharmaceuticals, unrelated to this work. K.A.V.-M. is an employee at Illumina. R.W.K. is an employee at Psomagen. R. Mehran reports institutional research grants from Abbott Laboratories, Abiomed, Applied Therapeutics, AstraZeneca, Bayer, Beth Israel Deaconess, Bristol Myers Squibb, CERC, Chiesi, Concept Medical, CSL Behring, DSI, Medtronic, Novartis Pharmaceuticals and OrbusNeich; consultant fees from Abbott Laboratories, Boston Scientific, CardiaWave, Chiesi, Janssen Scientific Affairs, Medscape/WebMD, Medtelligence (Janssen Scientific Affairs), Roivant Sciences, Sanofi and Siemens Medical Solutions; consultant fees paid to the institution from Abbott Laboratories and Bristol Myers Squibb; advisory board fees paid to the institution from Spectranetics/Philips/Volcano Corp.; consultant fees (spouse) from Abiomed, The Medicines Company and Merck; equity <1% from Claret Medical and Elixir Medical; DSMB membership fees paid to the institution from Watermark Research Partners; consulting (no fee) from Idorsia Pharmaceuticals and Regeneron Pharmaceuticals; and Associate Editor for American College of Cardiology (ACC) and American Medical Association (AMA). R. Malhotra is a consultant for MyoKardia (now owned by Bristol Myers Squibb), Epizon Pharma, Renovacor and Third Pole; is a co-founder of Patch and Angea Biotherapeutics; and has received research funding from Angea Biotherapeutics, Bayer Pharmaceuticals and Amgen. A.M.S. receives funding from Seven Bridges Genomics to develop tools for the NHLBI BioData Catalyst consortium. P.N. reports grants from Amgen, Apple, Boston Scientific, AstraZeneca, Allelica, Novartis and Genentech; consulting income from GV, Blackstone Life Sciences, Foresite Labs, Apple, AstraZeneca, Allelica, Novartis, HeartFlow and Genentech; being a scientific advisor to Esperion Therapeutics, Preciseli and TenSixteen Bio; being a scientific co-founder of TenSixteen Bio; and spousal employment at Vertex, all unrelated to the present work. C.L.M. received a research grant from AstraZeneca for an unrelated project. The remaining authors declare no competing interests.