Kong, Anthony
Kirkham, Amanda J.
Savage, Joshua S.
Mant, Rhys
Lax, Siân
Good, James
Forster, Martin D.
Sacco, Joseph J.
Schipani, Stephano
Harrington, Kevin J.
Yap, Christina
Mehanna, Hisham
Funding for this research was provided by:
Cancer Research UK (C19677/A20959, C19677/A20959, C19677/A20959)
AstraZeneca (n/a, n/a, n/a)
Article History
Received: 26 September 2023
Revised: 30 November 2023
Accepted: 14 December 2023
First Online: 29 January 2024
COMPETING INTERESTS
: AK has received fees for consulting, advisory, speaker’s roles and/or research funding from PUMA BioTechnology, AstraZeneca, Merck, MSD, Bristol-Myers Squibb, Avvinity Therapeutics. MDF has received research funding from Boehringer Ingelheim, MSD, and Merck, honoraria from Bayer and MSD, and has been on advisory boards Immutep, Pharmamar, Oxford VacMedix, Amgen, AstraZeneca, Boxer, EQRx, Merck, Bristol-Myers Squibb, Guardant Health, Roche, Takeda, UltraHuman, Celgene, and Janssen. JJS has received research funding from BMS and AstraZeneca. SS has received consulting fees and honoraria from Sanofi. CY has received research funding from Novartis, Faron Pharmaceuticals, AstraZeneca, and Celgene, honoraria from Celgene and Faron Pharmaceuticals, and fees for speaker’s role from Bayer. KJH has received consulting fees from AstraZeneca, Merck-Serono, and Merck-Sharp-Dohme. HM received honoraria from AstraZeneca, travel support from Merck, and has been on advisory boards for Eisai Inc, Nanobiotix, and Merck. HM, JSS, and RM received funds from Cancer Research UK and AstraZeneca to fund this study. All other authors declare no competing interests.
: The trial was sponsored by the University of Birmingham and run by the Cancer Research UK Clinical Trials Unit, University of Birmingham. Ethical approval for the trial protocol (ultimately Version 5.0, 27-Nov-2018) was obtained from West Midlands - Edgbaston Research Ethics Committee (16/WM/0501) and local institutional review boards in accordance with the ethical principles of the Declaration of Helsinki and Good Clinical Practice Guidelines. Signed informed consent was obtained from all patients before registration.