Williams, L M
Debattista, C
Duchemin, A-M
Schatzberg, A F
Nemeroff, C B
Article History
Received: 14 April 2015
Revised: 30 December 2015
Accepted: 5 March 2016
First Online: 3 May 2016
Competing interests
: The iSPOT-D sponsor central management team managed the operations of the sites and the data storage and quantification. Interpretation of the data was undertaken independently from the study sponsor and preparation and review of the manuscript was undertaken by the academic authors. LMW has received consultant fees from Brain Resource and from Humana. CD has received research funding from Brain Resource, St. Jude, Jannsen, Assurex, Roche, Takeda and has received consultant fees from Pfizer and Genentech. A-MD has received research funding from Brain Resource. AFS has served as a consultant to Bay City Capital, BrainCells, CeNeRx, Cervel, Depomed, Eli Lilly, Forum, Genentech, Gilead, Jazz, Lundbeck/Takeda, McKinsey, Merck, MSI, Neuronetics, Novadel, One-Carbon, PharmaNeuroBoost, Sunovion, Synosia and Xhale; he has received honoraria from Merck; he has equity in Amnestix, BrainCells, CeNeRx, Corcept (co-founder), Delpor, Forest, Merck, Neurocrine, Novadel, Pfizer, PharmaNeuroBoost, Somaxon, Synosis, Titan and Xhale; and he receives royalties from Stanford University for patents on mifepristone use and the pharmacogenetics of antidepressant response. In the last 3 years, CBN has received a Scientific Advisory Board/Board of Directors fee from PharmaNeuroboost, Clintara/Bracket, Xhale, Taisho, Fortress, Takeda, Janssen/Ortho-McNeil and George West Mental Health Foundation. He holds stock or stock options in Xhale, Clintara/Bracket, Seattle Genetics, Celgene, Titan and Network Life Sciences. CBN has patents for Methods and devices for the transdermal delivery of lithium (US 6 375 990 BI) and Method to estimate serotonin and norepinephrine transporter occupancy after drug treatment using patient or animal serum (provisional filing April 2001). LMW was the overall academic PI for iSPOT-D (2008–2013), CD is the PI for the Stanford iSPOT-D site, A-MD is co-I for the Ohio State iSPOT-D site, AFS is co-I for the Stanford iSPOT-D site and CBN is co-I for the Miami University iSPOT-D site. Analyses were undertaken by LMW, CD and CBN and all the authors participated in interpreting results and drafting the manuscript. CD and LMW had full access to all the data in the study and they take responsibility for the integrity of the data and the accuracy of the data analysis.