Hardin, M
Cho, M H
McDonald, M-L
Wan, E
Lomas, D A
Coxson, H O
MacNee, W
Vestbo, J
Yates, J C
Agusti, A
Calverley, P M A
Celli, B
Crim, C
Rennard, S
Wouters, E
Bakke, P
Bhatt, S P
Kim, V
Ramsdell, J
Regan, E A
Make, B J
Hokanson, J E
Crapo, J D
Beaty, T H
Hersh, C P
Crapo, James
Silverman, Edwin
Make, Barry
Regan, Elizabeth
Beaty, Terri
Laird, Nan
Lange, Christoph
Cho, Michael
Santorico, Stephanie
Hokanson, John
DeMeo, Dawn
Hansel, Nadia
Hersh, Craig
Castaldi, Peter
McDonald, Merry-Lynn
Wan, Emily
Hardin, Megan
Hetmanski, Jacqueline
Parker, Margaret
Foreman, Marilyn
Hobbs, Brian
Busch, Robert
El-Bouiez, Adel
Castaldi, Peter
Hardin, Megan
Qiao, Dandi
Regan, Elizabeth
Halper-Stromberg, Eitan
Begum, Ferdouse
Won, Sungho
Fredericksen, Brittney
Lutz, Sharon
Lynch, David A
Coxson, Harvey O
Han, MeiLan K
Hoffman, Eric A
Humphries, Stephen
Jacobson, Francine L
Judy, Philip F
Kazerooni, Ella A
Newell, John D
Regan, Elizabeth
Ross, James C
Estepar, Raul San Jose
Stoel, Berend C
Tschirren, Juerg
Rikxoort, Eva van
Ginneken, Bram van
Washko, George
Wilson, Carla G
Qaisi, Mustafa Al
Gray, Teresa
Kluiber, Alex
Mann, Tanya
Sieren, Jered
Stinson, Douglas
Schroeder, Joyce
Beek, Edwin Van
Jensen, Robert
Everett, Douglas
Faino, Anna
Strand, Matt
Wilson, Carla
Hokanson, John E
Black-Shinn, Jennifer
Kinney, Gregory
Lutz, Sharon
Pratte, Katherine
Curtis, Jeffrey
Martinez, Carlos
Pernicano, Perry G
Hanania, Nicola
Alapat, Philip
Bandi, Venkata
Atik, Mustafa
Boriek, Aladin
Guntupalli, Kalpatha
Guy, Elizabeth
Parulekar, Amit
Nachiappan, Arun
DeMeo, Dawn
Hersh, Craig
Washko, George
Jacobson, Francine
Graham Barr, R
Thomashow, Byron
Austin, John
D'Souza, Belinda
Pearson, Gregory D N
Rozenshtein, Anna
MacIntyre, Neil
Page McAdams, H
McEvoy, Charlene
Tashjian, Joseph
Wise, Robert
Hansel, Nadia
Brown, Robert
Horton, Karen
Putcha, Nirupama
Casaburi, Richard
Adami, Alessandra
Porszasz, Janos
Fischer, Hans
Budoff, Matthew
Cannon, Dan
Rossiter, Harry
Sharafkhaneh, Amir
Lan, Charlie
Wendt, Christine
Bell, Brian
Foreman, Marilyn
Westney, Gloria
Berkowitz, Eugene
Bowler, Russell
Lynch, David
Rosiello, Richard
Pace, David
Criner, Gerard
Ciccolella, David
Cordova, Francis
Dass, Chandra
D'Alonzo, Robert
Desai, Parag
Jacobs, Michael
Kelsen, Steven
Kim, Victor
James Mamary, A
Marchetti, Nathaniel
Satti, Aditti
Shenoy, Kartik
M. Steiner, Robert
Swift, Alex
Swift, Irene
Vega-Sanchez, Gloria
Nath, Hrudaya
Dransfield, Mark
Bailey, William
Michael Wells, J
Bhatt, Surya
Nath, Hrudaya
Ramsdell, Joe
Friedman, Paul
Soler, Xavier
Yen, Andrew
Cornellas, Alejandro
Newell, John
Thompson, Brad
Han, MeiLan
Kazerooni, Ella
Martinez, Fernando
Billings, Joanne
Allen, Tadashi
Sciurba, Frank
Chandra, Divay
Weissfeld, Joel
Fuhrman, Carl
Bon, Jessica
Anzueto, Antonio
Adams, Sandra
Maselli-Caceres, Diego
E Ruiz, Mario
Bourbeau, J
Fitzgerald, M
Hernández, P
Killian, K
Levy, R
Maltais, F
O'Donnell, D
Krepelka, J
Vestbo, J
Wouters, E
Quinn, D
Bakke, P
Kosnik, M
Agusti, A
Mallorca, Palma de
Feschenko, Y
Gavrisyuk, V
Yashina, L
Yashina, L
MacNee, W
Singh, D
Wedzicha, J
Anzueto, A
Braman, S
Casaburi, R
Celli, B
Giessel, G
Gotfried, M
Greenwald, G
Hanania, N
Mahler, D
Make, B
Rennard, S
Rochester, C
Scanlon, P
Schuller, D
Sciurba, F
Sharafkhaneh, A
Siler, T
Silverman, E
Wanner, A
Wise, R
Coxson, H
Crim, C
Edwards, L
Lomas, D
MacNee, W
Silverman, E
Tal Singer, R
Vestbo, J
Yates, J
Agusti, A
Calverley, P
Celli, B
Crim, C
Miller, B
MacNee, W
Rennard, S
Tal-Singer, R
Wouters, E
Yates, J
,
,
Article History
Received: 9 April 2014
Revised: 4 May 2015
Accepted: 18 May 2015
First Online: 27 October 2015
Competing interests
: Dr Michael Cho receives funding from the NIH and the Alpha-1 Foundation. Dr David Lomas has received grant support, honoraria and consultancy fees from GlaxoSmithKline. He chairs the GSK Respiratory Therapy Area Board. Dr Harvey Coxson has received $4800 in the years 2009–2012 for serving on the steering committee for the ECLIPSE project for GSK, he was the co-investigator on two multicenter studies sponsored by GSK and has received travel expenses to attend meetings related to the project. Dr Coxson has three contract service agreements with GSK (including the ECLIPSE study) to quantify the CT scans in subjects with COPD and a service agreement with Spiration to measure changes in lung volume in subjects with severe emphysema. He has received a fee for speaking at a conference and related travel expenses from AstraZeneca (Australia). Dr Coxson was the recipient of a GSK Clinical Scientist Award in 2010. Dr Jørgen Vestbo has received honoraria for consulting and presenting from Almirall, AstraZeneca, Boehringer-Ingelheim, Chiesi, GSK, Novartis and Takeda. Julie Yates is an employee of and owns stock in GlaxoSmithKline. Dr Alvar Agusti has consulted and received honoraria for lecturing at meeting from different pharmaceutical companies commercializing bronchodilators, including GSK, Boheringer-Ingelheim, AstraZeneca, Almirall, Novartis and Chiesi. Dr Celli has worked as a researcher or consultant for the following companies: GSK, Almirall, Novartis, Forrest, Aeris, Boehringer-Ingelheim, Dey, Altana, Pfizer, and Rox. Dr Courtney Crim is an employee of GlaxoSmithKline LLC, the sponsor of the ECLIPSE trial. He holds stock/stock options in GSK as a portion of his compensation as an employee. As it relates to this manuscript, Dr Crim declares no conflict of interest. Dr Rennard has had or currently has a number of relationships with companies who provide products and/or services relevant to outpatient management of chronic obstructive pulmonary disease. These relationships include serving as a consultant, advising regarding clinical trials, speaking at continuing medical education programs and performing funded research both at basic and clinical levels. He does not own any stock in any pharmaceutical companies. These companies include: AARC, American Board of Internal Medicine, Able Associates, Align2 Acton, Almirall, APT, AstraZeneca, American Thoracic Society, Beilenson, Boehringer Ingelheim, Chiesi, CIPLA, Clarus Acuity, CME Incite, COPDFoundation, Cory Paeth, CSA, CSL Behring, CTS Carmel, Dailchi Sankyo, Decision Resources, Dunn Group, Easton Associates, Elevation Pharma, FirstWord, Forest, GLG Research, Gilead, Globe Life Sciences, GlaxoSmithKline, Guidepoint, Health Advance, HealthStar, HSC Medical Education, Johnson and Johnson, Leerink Swan, LEK, McKinsey, Medical Knowledge, Medimmune, Merck, Navigant, Novartis, Nycomed, Osterman, Pearl, PeerVoice, Penn Technology, Pennside, Pfizer, Prescott, Pro Ed Communications, PriMed, Pulmatrix, Quadrant, Regeneron, Saatchi and Saatchi, Sankyo, Schering, Schlesinger Associates, Shaw Science, Strategic North, Summer Street Research, Synapse, Takeda, Telecon SC and ThinkEquity. Dr Per Bakke has consulted for Boehringer Ingelheim and received compensation. Professor Calverley has received funding from the UK MRC and holds an NIHR programme grant. He has been compensated for work on clinical trials steering committees for GSK, Boehringher Ingelheim and Takeda. He has spoken at meetings supported by these companies and by AstraZeneca, Novartis and Almirall. He holds no stock in any relevant concern and has no contacts with the tobacco industry. Dr Victor Kim has nothing to disclose in relationship to this manuscript but has served on an advisory committee for CSA and has participated in clinical trials sponsored by Boehringer Ingelheim, Glaxo-Smith-Kline and Roche pharmaceuticals. VK is supported by NHLBI K23HL094696-03. Dr Craig Hersh has received consulting fees from Novartis and CSL Behring.