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Article History

Received: 25 July 2023

Revised: 25 July 2023

Accepted: 2 August 2023

First Online: 4 July 2024

CONFLICT OF INTEREST

: The authors of this work declare that they have no conflicts of interest.

: The experimental work with the involvement of laboratory animals was carried out in accordance with generally accepted ethical standards for the treatment of animals, which are regulated by special rules adopted by the “European Convention for the Protection of Vertebrates Used for Research and Scientific Purposes (ETS, 123), Strasbourg, 1986,” as well as the bioethical standards given in the “Guide for care and use of laboratory animals (ILAR publication, National Academy Press, 1996)” and “Anticancer Drug Development Guide. Preclinical screening, clinical trials, and approval,” second ed. (Ed. by B.A. Teicher and P.A. Andrews) (Humana Press, Totowa, New Jersey, 2004, p. 450, and agreed with the Ethics Committee at the PRMU of the Ministry of Health of the Russian Federation (Rule No. 51 SP 2.2.1.3218-14 dated August 29, 2014). The executer of the work, Institute of Biochemical Physics, Russian Academy of Sciences, is included in the List of organizations and institutions conducting preclinical studies of medicines, based on the decision of the Ministry of Health of the Russian Federation (Permission of the Ministry of Health of the Russian Federation no. 01-45122/06 dated September 9, 2006).