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Article History

Received: 12 July 2021

Revised: 10 August 2021

Accepted: 14 August 2021

First Online: 26 May 2022

COMPLIANCE WITH ETHICAL STANDARDS

: Experiments with laboratory animals were carried out following the International Recommendations for the Protection of Vertebrates used in Experimental Studies (European Convention for the Protection of Vertebrates (Strasbourg, 1986), the Order of the Ministry of Health of the Russian Federation No. 199n (April 01, 2016), Principles of Good Laboratory Practice (OECD, ENV/MC/CUEM (98)17, 1997); Principles of Good Laboratory Practice (GOST 33044-2014 identical to GLPOECD), Good Laboratory Practice for Nonclinical Laboratory Studies (21 CFR part 58, 1978, USA, FDA); Good Laboratory Practice Standards (Ordinance No. 21, 1997, Japan, MHW), article 11 of Federal Law No. 61-FZ (April 12, 2010) “On the Circulation of Medicines,” and “Guidelines for Conducting Preclinical Studies of Medicines,” ed. A.N. Mironova (Moscow, 2012).The research was approved by the Ethics Committee of the Volgograd State Medical University of the Ministry of Health of Russia.

: The authors state that there is no conflict of interest.