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Article History

Received: 15 July 2024

Revised: 25 July 2024

Accepted: 30 July 2024

First Online: 31 October 2024

ETHICS APPROVAL AND CONSENT TO PARTICIPATE

: When conducting experiments with animals, all provisions of the “Policy for Working with Laboratory Animals of the Testing Center of the Preclinical Research Center of JSC GENERIUM, based on the main international standards "Directive 2010/63/EU of the European Parliament” and of the Council of 22.09.2010 “On the Protection of Animals used for Scientific Purposes”, and Appendix A to the “European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes” (ETS No. 123), were observed. Guidelines for the Care and Maintenance of Laboratory Animals (Article no. 5 of the Convention). The main conditions for keeping and handling animals, taking into account the “Three R” concept, were set out in the veterinary protocol, which was reviewed and approved by the Bioethics Commission of JSC GENERIUM (Minutes of the meeting of the Bioethics Commission No. 28/2014 dated October 17, 2014). No deviations from the veterinary protocol were found during the experiments. The authors confirm that the established ethical norms and standards for working with animals were observed during the experiments using animals.

: The authors of this work declare that they have no conflicts of interest.