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Inhibition of insulin degrading enzyme suppresses osteoclast hyperactivity via enhancing Nrf2-dependent antioxidant response in glucocorticoid-induced osteonecrosis of the femoral head

Crossref DOI link: https://doi.org/10.1186/s10020-024-00880-1

Published Online: 2024-07-31

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Yuan, Tao

Wang, Haojue

Wang, Yi

Dong, Shankun

Ge, Jianxun

Li, Ziqing

Sun, Shui https://orcid.org/0000-0002-9744-1595
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82272485)

National Natural Science Foundation of China (82100936)

Natural Science Foundation of Shandong Province (ZR2021QH077)

Taishan Scholar Foundation of Shandong Province (tsqnz20221170)
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Article History

Received: 2 March 2024

Accepted: 17 July 2024

First Online: 31 July 2024

Declarations

:

: All experiments involving mice were performed following the protocol approved by the Institutional Animal Care and Use Committee (IACUC) of the Shandong First Medical University (Shandong, China; No. LS2024021).

: Not applicable.

: The authors declare that they have no competing interests.

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