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Formononetin ameliorates depression-like behaviors through rebalancing microglia M1/M2 polarization and inhibiting NLRP3 inflammasome: involvement of activating PPARα-mediated autophagy

Crossref DOI link: https://doi.org/10.1186/s10020-025-01217-2

Published Online: 2025-04-24

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Peng, Shuaijun

Su, Pan

Liu, Liming

Li, Zibo

Liu, Yuan

Tian, Lei

Bai, Ming

Xu, Erping

Li, Yucheng
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82404882, 82274496)

Natural Science Fund of Henan Province (242300420428)

Henan Provincial Science and Technology Research Project (232301420018)
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Text and Data Mining valid from 2025-04-24

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Article History

Received: 29 December 2024

Accepted: 16 April 2025

First Online: 24 April 2025

Declarations

:

: All animal procedures were performed according to the National Institutes of Health (NIH) guide for the care and use of Laboratory Animals (NIH Publications No. 8023, revised 1978) and approved by the Committee of Animal Care of Henan University of Chinese Medicine (DWLLGZR202202033).

: All authors concur with the submission.

: The authors declare no competing interests.

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