Jena, Jayashree
Sood, Ayushi
Peterson, Joshua
García-Peña, Luis Miguel
Weatherford, Eric T.
Patel, Pritesh
Roitershtein, Shelly
Smith, David A.
Challa, Vamsi
Seeley, Randy J.
Pereira, Renata O.
Funding for this research was provided by:
National Institute of Diabetes and Digestive and Kidney Diseases
American Heart Association
National Institutes of Health
Article History
Received: 3 November 2025
Accepted: 7 May 2026
First Online: 18 May 2026
Declarations
:
: All mouse experiments described in this study were conducted in accordance with NIH animal research guidelines and were approved by the University of Iowa IACUC.Not applicable.
: Not applicable.
: R.J.S has received research support from Fractyl, AstraZeneca, Congruence Therapeutics, Eli Lilly, Diasome and Amgen. RJS has been a paid consultant for Novo Nordisk, Eli Lilly, CinRx, Crinetics, Amgen, Helicore, Gallant and Nuanced Health. RJS has equity in Nuanced Health, Coro Bio, Eccogene, Fractyl and Rewind. All other authors declare no competing interests.