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Single-cell transcriptomic profiling reveals PDK4 upregulation and impaired VEGF-C/VEGFR3 signaling in cardiac lymphatic endothelial cells in diabetic cardiomyopathy

Crossref DOI link: https://doi.org/10.1186/s10020-026-01571-9

Published Online: 2026-07-16

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Yan, Yufeng

Wang, Xunuo

Zhu, Congfei

Jiang, Zihao

Wang, Jing

He, Junjie

Xu, Lei

Zhou, Xiaobin

Ge, Qing

Hu, Zuoying

Zuo, Guangfeng
Funding

Funding for this research was provided by:

Basic Research Program of Jiangsu (BK20250263)

National Natural Science Foundation of China (82170363)
License Information

Text and Data Mining valid from 2026-07-16

Accepted Manuscript valid from 2026-07-16
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Article History

Received: 18 April 2026

Accepted: 10 July 2026

First Online: 16 July 2026

Declarations

Ethics approval and consent to participate: All experimental protocols were approved by the Institutional Animal Care and Use Committee of Nanjing First Hospital (DWSY-22061192).

Consent for publication: Not applicable.

Competing interests: The authors declare no competing interests.

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