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Article History

Received: 11 April 2019

Accepted: 27 May 2019

First Online: 3 June 2019

Ethics approval and consent to participate

: Both trials are registered with ClinicalTrials.gov (NCT02614261; NCT02174861). The study protocol was approved by the appropriate ethics committee at each site. Patients provided written informed consent.

: Not applicable.

: BR has received honoraria for consulting from Novartis Pharma. VM reports no disclosures. HI has received honoraria for consulting from Pharm Allergan and Autonomic Technologies. LN has received honoraria for consulting from Eli Lilly and Novartis Pharma, and for scientific presentations by Pharm Allergan, Desitin, Hormosan, Eli Lilly, Novartis Pharma and TEVA. UR has received honoraria for consulting from Amgen, Pharm Allergan, Autonomic Technologies, Co-Lucid, Eli Lilly, Medscape; StreaMedUp, Novartis Pharma and TEVA, and for scientific presentations by Amgen, Allergan, Eli Lilly, Co-Lucid, Medscape, Novartis Pharma and TEVA. BR, HI, LN and UR are involved as investigators in clinical trials with monoclonal antibodies from Amgen, Alder, Eli Lilly, Novartis, and TEVA without personal remuneration.