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Article History

Received: 3 November 2021

Accepted: 18 November 2021

First Online: 18 December 2021

Declarations

:

: All patients provided written informed consent. The EARLY study received approval no.19/26 from the IRCCS San Raffaele Roma Institutional Review Board, while the GARLIT study was approved by the Campus Bio-Medico University Ethical Committee n.30/20. The other local Institutional Review Boards mutually recognized the approvals. The GARLIT study has been registered at the Italian Medicines Agency (Agenzia Italiana del Farmaco, AIFA) and atNCT04803513.

: Not applicable.

: Fabrizio Vernieri received travel grants, honoraria for advisory boards, speaker panels, or clinical investigation studies from Allergan, Amgen, Angelini, Eli-Lilly, Lundbeck, Novartis, and Teva.Roberta Messina received honoraria as speaker from Novartis, Eli Lilly, and Teva.Bruno Colombo received travel grants, honoraria for advisory boards, speaker panels, or clinical investigation studies from Novartis, Teva, Eli-Lilly Lusofarmaco Paola Torelli received travel grant, honoraria as a speaker, or for participating in advisory boards from Novartis, Teva, Eli Lilly, and Allergan.Sabina Cevoli received travel grants, honoraria for advisory boards, speaker panels or clinical investigation studies from Novartis, Teva, Lilly, Allergan, Ibsa, Amgen and Lundbeck.Valentina Favoni received honoraria as speaker or for participating in advisory boards from Ely-Lilly, Novartis and Teva.Florindo d’Onofrio received grants and honoraria from Lilly, Teva, Novartis, Neopharmed.Gabriella Egeo received travel grants and honoraria from Eli-Lilly, Novartis, New Penta and Ecupharma.Renata Rao received honoraria for speaker panels from Teva, Lilly, Novartis.Massimo Filippi is the Editor-in-Chief of the Journal of Neurology; received compensation for consulting services and/or speaking activities from Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries; and receives research support from Biogen Idec, Merck-Serono, Novartis, Roche, Teva Pharmaceutical Industries, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, and AriSLA (Fondazione Italiana di Ricerca per la SLA).Piero Barbanti received travel grants, honoraria for advisory boards, speaker panels or clinical investigation studies from Alder, Allergan, Angelini, Bayer, ElectroCore, Eli-Lilly, GSK, Lusofarmaco, MSD, Novartis, Stx-Med, Teva, Visufarma, Zambon.Claudia Altamura received travel grants and honoraria from Novartis, Eli Lilly, Lusofarmaco, Laborest, Allergan, Almirall.Nicoletta Brunelli, Simone Quintana and Carmelina Maria Costa have nothing to disclose.