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Inhibition of S100A4 decreases neurotoxic astrocyte reactivity and attenuates neuropathic pain via the TLR4/NF-κB pathway in a rat model of spinal nerve ligation

Crossref DOI link: https://doi.org/10.1186/s10194-025-02045-9

Published Online: 2025-05-01

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Xue, Tao

Song, Yu

Zhao, Jie

Fan, Guiyong

Liu, Zhiyuan
Funding

Funding for this research was provided by:

the Science and Technology Project of Changzhou Health Commission (WZ202227)

the Changzhou Sci&Tech Program (CJ20245003)

the Science and Technology Development Foundation of the affiliate hospitals of Xuzhou Medical university (XYFM202464)

the Medical Research Project of Jiangsu Health Commission (Z2022045)
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Text and Data Mining valid from 2025-05-01

Version of Record valid from 2025-05-01
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Article History

Received: 7 March 2025

Accepted: 23 April 2025

First Online: 1 May 2025

Declarations

:

: Animal procedures were conducted in accordance with the guidelines of the International Association for the Study of Pain and approved by the Animal Care and Use Committee of Jiangsu University.

: Not applicable.

: The authors declare no competing interests.

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