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Authors
Chen, Jiajie
Xu, Guifeng
Xie, Zhipeng
Xie, Shaoxia
Luo, Wenwei
Zhong, Shilong
Lai, Weihua https://orcid.org/0000-0001-6093-329X
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Funding
Funding for this research was provided by:
National Natural Science Foundation of China (No. 82274016)
National Natural Science Foundation of China (81872934)
National Natural Science Foundation of China (82003746)
National Natural Science Foundation of China (82473910)
Leading Talent of Guangdong Special Support Program (0720240120)
Guangdong Basic and Applied Basic Research Foundation (2021A1515220031)
Basic and Applied Basic Research Foundation of Guangdong Province (2023A1515011133)
Basic and Applied Basic Research Foundation of Guangdong Province (2025A1515012395)
Science and Technology Program of Guangzhou (No. 2023B03J1251)
Key-Area Research and Development Program of Guangdong Province, China (No. 2019B020229003)
National key research and development program (No. 2017YFC0909301)
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Article History
Received: 17 February 2025
Accepted: 23 June 2025
First Online: 18 July 2025
Declarations
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: The Ethics Review Committee of Guangdong Provincial People’s Hospital approved our human and animal studies (no. GDREC:KY2023-090-02) on 10 March 2023, in compliance with the “Ethical Review Measures for Biomedical Research Involving Human Subjects” and “Guidance on the Humane Treatment of Laboratory Animals” issued by the Ministry of Science and Technology of China, as well as relevant international animal welfare guidelines and regulations (including the ICLAS statement). Our research strictly adhered to the Declaration of Helsinki and other applicable guidelines. The study was registered with ClinicalTrials.gov (NCT03092076) and was strictly conducted in accordance with the relevant provisions of the Declaration of Helsinki and received approval from the Medical Research Ethics Committee of Guangdong Provincial People’s Hospital (no. GDREC2015143H(R1) and no. GDREC2017071H). Each patient was fully informed of the details of the research and the entire process. Furthermore, written informed consent was obtained from all participants (no. 20150115 and no.20170211).
: The authors declare that they have no competing interests.
