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Authors
Zhu, Yichen
Han, Jing
Pan, Yan
Liu, Yan
Zhang, Zhe
Chen, Haiyang
Zhou, Si
Sun, Zhenqiang
Liu, Yang
Wang, Qiming
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Funding
Funding for this research was provided by:
Henan Province Health and Youth Subject Leader Training Project ([2020]60)
Leading Talent Cultivation Project of Henan Health Science and Technology Innovation Talents (YXKC2020009)
ZHONGYUAN QIANREN JIHUA (ZYQR201912118)
Henan International Joint Laboratory of drug resisitance and reversal of targeted therapy for lung cancer ([2021]10)
Henan Medical Key Laboratory of Refractory lung cancer ([2020]27)
Henan Refractory Lung Cancer Drug Treatment Engineering Technology Research Center ([2020]4)
the 51282 project Leading Talent of Henan Provincial Health Science and Technology Innovation Talents ([2016]32)
Huilan Charity Fund (HL-HS2020-129)
National Natural Science Foundation of China (81872204)
Henan Province Young and Middle-aged Health Science and Technology Innovation Leading Talent Project (YXKC2022004)
The Provincial and Ministry Co-constructed Key Projects of Henan Medical Science and Technology (SBGJ202401004)
Henan Province Health Young and Middle-Aged Discipline Leader Project (HNSWJW-2022011)
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Article History
Received: 19 February 2025
Accepted: 28 July 2025
First Online: 10 December 2025
Declarations
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: Approval for the acquisition of patient tissues and clinicopathological data was granted by the Medical Ethics Committee of the Affiliated Cancer Hospital of Zhengzhou University (review number: 2022-ky-0069–002; approval date: July 2022) in accordance with the ethical principles outlined in the Declaration of Helsinki. The animal experiments were authorized by the Ethics Committee for Animal Experiments at Zhengzhou University (review number: ZZU-LAC2024090322; approval date: September 2024), which operates in compliance with the International Council for Laboratory Animal Science (ICLAS) guidelines. Both committees ensured that all procedures adhered to rigorous ethical standards, safeguarding the rights and welfare of human participants and laboratory animals throughout the study.
: The authors declare no competing interests.
