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Gut microbiota-derived trimethylamine N-oxide contributes to cardiomyocyte pyroptosis and cardiac injury via the tRF-Glu–ANT1–GSDMD axis

Crossref DOI link: https://doi.org/10.1186/s11658-026-00873-4

Published Online: 2026-02-24

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Wang, Tao

Ren, Weibin

Chen, Xinzhe

Wang, Xueyao

Liu, Miaomiao

Zhang, Yanhui

Li, Zhaoshui

Wang, Yanbo

Song, Zhiqiang

Diao, Hongyan
Funding

Funding for this research was provided by:

Shandong Provincial Natural Science Foundation (ZR2024QH017)

Shandong Provincial Natural Science Foundation (ZR2024QH318)

National Natural Science Foundation of China (8240022434)

the National Key Research and Development Program of China (2021YFA1301100)

Shandong Provincial Laboratory Project (SYS202202)

Research Project of Jinan Microecological Biomedicine Shandong Laboratory (JNL-2022001A)

Research Project of Jinan Microecological Biomedicine Shandong Laboratory (JNL-2023009Q)
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Text and Data Mining valid from 2026-02-24

Version of Record valid from 2026-03-31
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Article History

Received: 8 June 2025

Accepted: 29 January 2026

First Online: 24 February 2026

Declarations

:

: All procedures with animals were approved by the Ethics Committee of Jinan Microecological Biomedicine Shandong Laboratory following the Basel Declaration. Ethics Approval was granted by the Ethics Committee of Jinan Microecological Biomedicine Shandong Laboratory (approval no. 202416, 14th June 2024). The Ethics Committee of Jinan Microecological Biomedicine Shandong Laboratory adheres to the principles and guidelines set forth by the International Council for Laboratory Animal Science (ICLAS), ensuring that our animal research meets international ethical standards.

: Not applicable.

: The authors have declared that no competing interests exist.

: Not applicable.

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