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Does TXA reduce total volume of 24-hour blood products transfused in post-traumatic hemorrhage in a resource-constrained setting:Secondary analysis of a prospective cohort trauma study in South Africa.

Crossref DOI link: https://doi.org/10.1186/s12245-025-00972-7

Published Online: 2025-09-30

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Dymond, Chelsea

Xiao, Mengli

Finck, Lani

Lategan, Hendrick

Oosthuizen, George

de Vries, Shaheem

Verster, Janette

Wylie, Craig

Collaborators, EpiC Study Site

Stassen, Willem

Maddry, Joseph

Schauer, Steven

Dixon, Julia

Mould-Millman, Nee-Kofi
Funding

Funding for this research was provided by:

U.S. Department of Defense (W81XWH-20-2-0042, F2MTW8-22-99-GW01.)
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Text and Data Mining valid from 2025-09-30

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Article History

Received: 29 April 2025

Accepted: 6 August 2025

First Online: 30 September 2025

Declarations

:

: Ethics approval for the EpiC study was provided by the Stellenbosch University Health Research Ethics Committee, the primary approving IRB (Project ID 14866; Ref. No. N20/03/036), with a single-site reliance issued by the Colorado Multiple Institutional Review Board (Protocol # 20–2176) and the US Department of Defense Office of Human Research Oversight. The study was approved to use a waiver of patient informed consent, therefore no patient consent was required nor collected. The study was conducted in accordance with the Declaration of Helsinki.

: Not applicable.

: The authors declare no competing interests.

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