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Article History

Received: 26 February 2018

Accepted: 6 June 2018

First Online: 20 June 2018

Ethics approval

: Experiments were performed according to the guidelines established in the NIH Guide for the Care and Use of Laboratory Animals (National Research Council, 2011). Animals were treated humanely for alleviation of potential suffering, as approved by the National Institute of Environmental Health Sciences Animal Care and Use Committee.

: JFF, SR, GGS, RAH, RCS and BAM are employees of the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), of the United States Government. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of NIEHS, NIH or the United States Government. DPP and RRS are Bioinformaticians at Sciome, LLC and performed exome sequence location and annotation under NIEHS contract HHSN273201700001C under NIEHS supervision. OH, VM and SH comprised the team from Agilent Technologies that formulated the probe library for exome enrichment. JFF, SR, GGS, RAH, RCS and BAM supplied biological materials and isolated DNA to test the probe library for exome enrichment provided by Agilent. The NIEHS Epigenomics core facility (GGS) performed the exome sequencing. KH, KK, CL and AM are researchers at the Genomics Laboratory of LabCorp-Covance performed Sanger validation of targeted sequence variants under NIEHS contract HHSN273201500005I under NIEHS supervision. Neither Sciome, LabCorp-Covance or Agilent contributed financial funding for publication of this work. The authors adhere to policies on public sharing of data and materials.