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Article History

Received: 17 August 2018

Accepted: 29 January 2019

First Online: 15 February 2019

Ethics approval and consent to participate

: This study was approved annually by the Washington University School of Medicine Institutional Review Board (IRB ID 201104208). It was performed in accordance with the Declaration of Helsinki. Informed written consent was obtained from participants after the nature and possible consequences of the studies were explained. Specimens were de-identified and all identifying information was secured to protect subjects from risks associated with participating in genomic studies.

: Not applicable.Datasets used are publicly available and sources are listed in the Data Sources above and in PLAIDOH documentation (). Additional post-process data tables used to generate figures for the manuscript are available from the corresponding author on reasonable request.

: The authors declare that they have no competing interests.

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