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Article History

Received: 17 March 2022

Accepted: 12 July 2022

First Online: 31 July 2022

Declarations

:

: Written informed consent was obtained previously from all participants of the LL, LLS, NTR and RS biobanks in accordance with the ethical and institutional regulations. The LL study was approved by the ethics committee of the University Medical Centre Groningen, document no. METC UMCG LLDEEP: M12.113965. All participants signed an informed consent form prior to study enrolment []. The Leiden Longevity Study was approved by the Medical Ethical Committee of the Leiden University Medical Center (METC LDD) and informed consent was obtained from all subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards []. The Netherlands Twin Register [] study protocol was approved by the Central Ethics Committee on Research Involving Human Subjects of the VU University Medical Centre, Amsterdam, an Institutional Review Board registered with the U.S. Office of Human Research Protections (Institutional Review Board no. IRB00002991, Federal-wide Assurance no. FWA00017598). The study is registered with the Dutch Data Protection Authority (no. m1412317). In accordance with the Declaration of Helsinki, the Netherlands Twin Register obtained informed consent from all participants prior to their entering the study. The Rotterdam Study has been approved by the institutional review board (Medical Ethics Committee) of the Erasmus Medical Center (registration number MEC 02.1015) and by the Dutch Ministry of Health, Welfare and Sport (Population Screening Act WBO, license number 1071272-159521-PG). The Rotterdam Study Personal Registration Data collection is filed with the Erasmus MC Data Protection Officer under registration number EMC1712001. The Rotterdam Study has been entered into the Netherlands National Trial Register (NTR; []) under catalogue number Trial NL6645 (NTR6831). All participants provided written informed consent to participate in the study and to have their information obtained from treating physicians [,].

: Not applicable.

: The authors declare that they have no competing interests.