Luo, Rongbo
Shen, Beilei
Qian, Bingshuo
Fan, Lingjun
Zhang, Junkui
Deng, Xiuwen
Sun, Yan
Zhang, Shijun
Wang, Tiecheng
Li, Yuanguo
Sun, Weiyang
Pang, Xiaobin
Zhong, Wu
Gao, Yuwei
Funding for this research was provided by:
the National Key Research and Development Program of China (2023YFC0871000)
Article History
Received: 21 November 2024
Accepted: 25 February 2025
First Online: 15 May 2025
Declarations
:
: Animal experiments were conducted following the protocols of the Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences (approval number: IACUC of AMMS-11-2022-036). The mice were anaesthetized via inhalation of 2.0% isoflurane, infected with nasal viral drops, and then naturally awakened. The endpoint of observation was defined as either natural death or a weight less than 75% of the original weight. The mice were euthanized once their weight was lower than 75% of the initial body weight via the inhalant euthanasia agent carbon dioxide. Additionally, all influenza virus infection experiments were conducted in a biosafety level 2 laboratory, and all SARS-CoV-2 infection experiments were conducted in a biosafety level 3 laboratory according to biosafety regulations.
: Not applicable.
: The authors declare no competing interests.