Crossmark

Dexmedetomidine pretreatment improves postsurgical delay in neurocognitive recovery in aged mice by inhibiting hippocampal microglial activation via activation of cholinergic anti-inflammatory pathways

Crossref DOI link: https://doi.org/10.1186/s12868-025-00969-1

Published Online: 2025-10-15

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zhang, Qidi

Hao, Shiyu

Wang, Guicheng

Liu, Chengxiao

Wang, Gongming

Zhang, Jie

Zhao, Jinyang

Li, Xiaowei

Li, Jingjing

Wu, Jiangnan

Wang, Xu
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (NSFC81971010, NSFC81971010)

Science and Technology Program Project of Jinan (202019178)
License Information

Text and Data Mining valid from 2025-10-15

Version of Record valid from 2025-10-15
More Information

Article History

Received: 5 February 2025

Accepted: 5 August 2025

First Online: 15 October 2025

Declarations

:

: The animal study protocol was reviewed and approved by the Animal Ethics Committee for Animal Experiments of Shandong First Medical University and Provincial Hospital of Shandong First Medical University (Approval Number INKJ: NO.2020–3032). All experimental procedures were conducted in accordance with the guidelines and regulations set by the committee to ensure the ethical treatment of animals. No additional consent was required as the study did not involve human participants.

: Not applicable.

: The authors declare no competing interests.

Document is current

Any future updates will be listed below