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Exploring extracellular vesicle surface markers and microRNA regulation following remote ischemic conditioning in patients with stroke; a randomized-controlled pilot study

Crossref DOI link: https://doi.org/10.1186/s12868-025-00993-1

Published Online: 2026-01-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Best Jensen, Rebecca

Kjølhede, Maria

Just, Jesper

Clegg, Lee-Ann

Baek, Rikke

Kaadt, Erik

Elfving, Betina

Hess, David C.

Andersen, Grethe

Jørgensen, Malene Møller

Blauenfeldt, Rolf Ankerlund

Drasbek, Kim Ryun https://orcid.org/0000-0003-2701-2741
Funding

Funding for this research was provided by:

Novo Nordisk Fonden (NNF20OC00060998)

Novo Nordisk Fonden (NNF20OC00060998)

Danish Neurological Society

Harboefonden

Danish Society for Neuroscience
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Text and Data Mining valid from 2026-01-12

Version of Record valid from 2026-02-09
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Article History

Received: 20 March 2025

Accepted: 29 December 2025

First Online: 12 January 2026

Declarations

:

: The study was approved by the Central Denmark Region Committees on Health Research Ethics (ID no. 1-10-72-184-19) and the Danish Medicines Agency (jr. no. 2019081802, EUDAMED CIV-ID nr. 19-08-029484) and was registered in the Region’s Internal List of research projects (ID no. 1-16-02-333-19). Clinicaltrial.gov identifier: NCT04266639 (registration date: 2020-03-12). The study was monitored by the Good Clinical Practice unit Aalborg/Aarhus, Denmark. All patients signed an informed consent form before enrolling in the study. The study adheres to the CONSORT guidelines.

: Not applicable.

: The authors declare no competing interests.

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