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Comparison of fractionated versus bolus administration of different doses of hyperbaric bupivacaine combined with opioids in spinal anesthesia for caesarean section – a prospective, randomized, participant-blind clinical trial

Crossref DOI link: https://doi.org/10.1186/s12871-026-03813-z

Published Online: 2026-04-07

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Kuchyn, Iurii

Bielka, Kateryna

Nimkovych, Roman

Sirenko, Ihor
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Text and Data Mining valid from 2026-04-07

Version of Record valid from 2026-05-18
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Article History

Received: 13 October 2025

Accepted: 1 April 2026

First Online: 7 April 2026

Declarations

:

: This prospective, randomized, participant-blind clinical trial was conducted following approval by the Institutional Ethics Committee of Bogomolets National Medical University (protocol No. 196, dated June 23, 2024). All participants provided written informed consent to participation in this study. The trial was conducted in accordance with the ethical standards of the institutional and national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

: Not applicable (all data were anonymized, and no individual identifying information is included in this article).

: The authors declare no competing interests.

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