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Authors
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Schmidt, Amand F. http://orcid.org/0000-0003-1327-0424
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Holmes, Michael V.
Preiss, David
Swerdlow, Daniel I.
Denaxas, Spiros
Fatemifar, Ghazaleh
Faraway, Rupert
Finan, Chris
Valentine, Dennis
Fairhurst-Hunter, Zammy
Hartwig, Fernando Pires
Horta, Bernardo Lessa
Hypponen, Elina
Power, Christine
Moldovan, Max
van Iperen, Erik
Hovingh, Kees
Demuth, Ilja
Norman, Kristina
Steinhagen-Thiessen, Elisabeth
Demuth, Juri
Bertram, Lars
Lill, Christina M.
Coassin, Stefan
Willeit, Johann
Kiechl, Stefan
Willeit, Karin
Mason, Dan
Wright, John
Morris, Richard
Wanamethee, Goya
Whincup, Peter
Ben-Shlomo, Yoav
McLachlan, Stela
Price, Jackie F.
Kivimaki, Mika
Welch, Catherine
Sanchez-Galvez, Adelaida
Marques-Vidal, Pedro
Nicolaides, Andrew
Panayiotou, Andrie G.
Onland-Moret, N. Charlotte
van der Schouw, Yvonne T.
Matullo, Giuseppe
Fiorito, Giovanni
Guarrera, Simonetta
Sacerdote, Carlotta
Wareham, Nicholas J.
Langenberg, Claudia
Scott, Robert A.
Luan, Jian’an
Bobak, Martin
Malyutina, Sofia
Pająk, Andrzej
Kubinova, Ruzena
Tamosiunas, Abdonas
Pikhart, Hynek
Grarup, Niels
Pedersen, Oluf
Hansen, Torben
Linneberg, Allan
Jess, Tine
Cooper, Jackie
Humphries, Steve E.
Brilliant, Murray
Kitchner, Terrie
Hakonarson, Hakon
Carrell, David S.
McCarty, Catherine A.
Lester, Kirchner H.
Larson, Eric B.
Crosslin, David R.
de Andrade, Mariza
Roden, Dan M.
Denny, Joshua C.
Carty, Cara
Hancock, Stephen
Attia, John
Holliday, Elizabeth
Scott, Rodney
Schofield, Peter
O’Donnell, Martin
Yusuf, Salim
Chong, Michael
Pare, Guillaume
van der Harst, Pim
Said, M. Abdullah
Eppinga, Ruben N.
Verweij, Niek
Snieder, Harold
Christen, Tim
Mook-Kanamori, D. O.
Gustafsson, Stefan
Lind, Lars
Ingelsson, Erik
Pazoki, Raha
Franco, Oscar
Hofman, Albert
Uitterlinden, Andre
Dehghan, Abbas
Teumer, Alexander
Baumeister, Sebastian
Dörr, Marcus
Lerch, Markus M.
Völker, Uwe
Völzke, Henry
Ward, Joey
Pell, Jill P.
Meade, Tom
Christophersen, Ingrid E.
Maitland-van der Zee, Anke H.
Baranova, Ekaterina V.
Young, Robin
Ford, Ian
Campbell, Archie
Padmanabhan, Sandosh
Bots, Michiel L.
Grobbee, Diederick E.
Froguel, Philippe
Thuillier, Dorothée
Roussel, Ronan
Bonnefond, Amélie
Cariou, Bertrand
Smart, Melissa
Bao, Yanchun
Kumari, Meena
Mahajan, Anubha
Hopewell, Jemma C.
Seshadri, Sudha
Dale, Caroline
Costa, Rui Providencia E.
Ridker, Paul M.
Chasman, Daniel I.
Reiner, Alex P.
Ritchie, Marylyn D.
Lange, Leslie A.
Cornish, Alex J.
Dobbins, Sara E.
Hemminki, Kari
Kinnersley, Ben
Sanson, Marc
Labreche, Karim
Simon, Matthias
Bondy, Melissa
Law, Philip
Speedy, Helen
Allan, James
Li, Ni
Went, Molly
Weinhold, Niels
Morgan, Gareth
Sonneveld, Pieter
Nilsson, Björn
Goldschmidt, Hartmut
Sud, Amit
Engert, Andreas
Hansson, Markus
Hemingway, Harry
Asselbergs, Folkert W.
Patel, Riyaz S.
Keating, Brendan J.
Sattar, Naveed
Houlston, Richard
Casas, Juan P.
Hingorani, Aroon D.
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Funding
Funding for this research was provided by:
British Heart Foundation (SP/13/6/30554, RG/10/12/28456, FS/18/23/33512)
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Article History
Received: 12 April 2019
Accepted: 19 August 2019
First Online: 29 October 2019
Ethics approval and consent to participate
: Local ethics committees for studies contributing data to these analyses granted approval for the work.
: Not applicable
: Dr. Holmes has collaborated with Boehringer Ingelheim in research, and in accordance with the policy of the The Clinical Trial Service Unit and Epidemiological Studies Unit (University of Oxford), did not accept any personal payment. David Preiss consulted for Amgen on a single occasion but, in accordance with the policy of the Clinical Trial Service Unit (University of Oxford), did not accept any personal payment. He is an investigator on a clinical trial of the PCSK9 synthesis inhibitor, inclisiran, funded by a grant to the University of Oxford by the Medicines Company, but he receives no personal fees from this grant. Daniel I Swerdlow is an employee of BenevolentAI Ltd. Aroon Hingorani and Harry Hemingway are National Institute for Health Research Senior Investigators. Naveed Sattar consulted for Amgen and Sanofi related to PCSK9 inhibitors; and was an investigator on clinical trials of PCSK9 inhibition funded by Amgen. Naveed Sattar has also consulted for Boehringer Ingelheim, Janssen, Eli-Lilly and NovoNordisk. Daniel Swerdlow has consulted to Pfizer for work unrelated to this paper. Folkert W. Asselbergs is supported by UCL Hospitals NIHR Biomedical Research Centre. Dr. Patel has received honoraria and speaker fees from Sanofi, Amgen and Bayer. Kees Hovingh or his institution (AMC) received honoraria for consultancy, ad boards, and/or conduct of clinical trials from: AMGEN, Aegerion, Pfizer, Astra Zeneca, Sanofi, Regeneron, KOWA, Ionis pharmaceuticals and Cerenis. Bertrand Cariou has received research funding from Pfizer and Sanofi, received honoraria from AstraZeneca, Pierre Fabre, Janssen, Eli-Lilly, MSD Merck & Co., Novo-Nordisk, Sanofi, and Takeda, and has acted as a consultant/advisory panel member for Amgen, Eli Lilly, Novo-Nordisk, Sanofi, and Regeneron. Andrzej Pająk acted as a consultant/advisory pannel member for Amgen. Erik Ingelsson is a scientific advisor for Precision Wellness and Olink Proteomics for work unrelated to this paper. JCH is a scientific advisor to a clinical trial of PCSK9 inhibition. AE Honoraria: Takeda, BMS, Amgen; Consulting: Takeda, BMS, Amgen. SEH acknowledges BHF funding (PG008/08) and support from the UCL BRC. All other authors declare no competing interests.
