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Article History

Received: 29 June 2021

Accepted: 26 November 2021

First Online: 13 February 2022

Declarations

:

: Both studies were conducted in accordance with the International Council for Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use Good Clinical Practice ethical principles, as outlined in the Declaration of Helsinki. The Phase 2 study protocol and procedures were reviewed and approved by UK Medicines and Healthcare Products Regulatory Agency, Food and Drug Administration's Center for Drug Evaluation and Research and National Research Ethics committee of Services Committee South West—Central Bristol, Partners Human Research Committee—Somerville. The PET study protocol and procedures were reviewed and approved by the Swedish Medical Products Agency and the Regional Ethical Review Board, Uppsala University Dnr 2017/498. Written informed consent was obtained from each patient for both studies.

: Not relevant.

: AW1 has received consultancy fees from GSK. WA-A, MB, SB, CC, MC, LC, MAL, HM, DR, IS, JS2, RLJ, PG, and DT are employees of or hold stocks/shares in GSK. JC is a fulltime Cambridge University Hospitals NHS Foundation Trust employee who was seconded for 50% of his NHS time to the GSK unit in Cambridge until September 2020. He received no employee benefits from GSK. RHF, RYK received research funding from GSK in support of the work provided by the CMR core laboratory. GW has received lecture fees from Novartis, Orion-Pharma, and Actelion. Outside of office hours Professor Wikström received remuneration from CTC. JS1 has no competing interests. SDS has received research grants from Actelion, Alnylam, Amgen, AstraZeneca, Bellerophon, Bayer, BMS, Celladon, Cytokinetics, Eidos, Gilead, GSK, Ionis, Lilly, Lone Star Heart, Mesoblast, MyoKardia, NIH/NHLBI, Neurotronik, Novartis, NovoNordisk, Respicardia, Sanofi Pasteur, and Theracos, and has consulted for Abbott, Action Akros, Alnylam, Amgen, Arena, AstraZeneca, Bayer, Boehringer Ingelheim, BMS, Cardior, Cardurion, Corvia, Cytokinetics, Daiichi-Sankyo, Gilead, GSK, Ironwood, Lilly, Merck, Myokardia, Novartis, Roche, Takeda, Theracos, Quantum Genetics, Cardurion, AoBiome, Janssen, Cardiac Dimensions, Tenaya, Sanofi-Pasteur, Dinaqor, Tremeau, CellProThera, Moderna, and American Regent. GA and AW2: report no conflicts of interest. GvD: received funding from GSK for [⁸⁹Zr]Zr-dezamizumab development and production. He has an unpaid position of Chief Scientific Officer (CSO) at LinXis biopharmaceuticals. DJV: received funding from GSK for [⁸⁹Zr]Zr-dezamizumab development and production.