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Domestic water hardness, genetic susceptibility, and risk of symptomatic abdominal aortic aneurysm: a cohort study of UK biobank

Crossref DOI link: https://doi.org/10.1186/s12872-025-05499-6

Published Online: 2026-01-23

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Li, Chenshu

Huang, Qun

Liu, Kailang

Wang, Xinggang

Qiu, Peng

Wang, Ruihua
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82170411, 82300540, 82170509, 82370494)

National Natural Science Foundation of China (82170411, 82300540, 82170509, 82370494)

National Natural Science Foundation of China (82170411, 82300540, 82170509, 82370494)

National Natural Science Foundation of China (82170411, 82300540, 82170509, 82370494)

National Natural Science Foundation of China (82170411, 82300540, 82170509, 82370494)

National Natural Science Foundation of China (82170411, 82300540, 82170509, 82370494)

Clinical Research Program of the 9th People's Hospital (JYLJ202010)

Clinical Research Program of the 9th People's Hospital (JYLJ202010)

Clinical Research Program of the 9th People's Hospital (JYLJ202010)

Clinical Research Program of the 9th People's Hospital (JYLJ202010)

Clinical Research Program of the 9th People's Hospital (JYLJ202010)

Clinical Research Program of the 9th People's Hospital (JYLJ202010)

Shanghai STC Innovative Medical Product Application Demonstration Project (25SF1905004,25SF1905000,25SF1904800,25SF1905100)

Shanghai STC Innovative Medical Product Application Demonstration Project (25SF1905004,25SF1905000,25SF1904800,25SF1905100)

Shanghai STC Innovative Medical Product Application Demonstration Project (25SF1905004,25SF1905000,25SF1904800,25SF1905100)

Shanghai STC Innovative Medical Product Application Demonstration Project (25SF1905004,25SF1905000,25SF1904800,25SF1905100)

Shanghai STC Innovative Medical Product Application Demonstration Project (25SF1905004,25SF1905000,25SF1904800,25SF1905100)

Shanghai STC Innovative Medical Product Application Demonstration Project (25SF1905004,25SF1905000,25SF1904800,25SF1905100)

Shanghai Ninth People's Hospital Medical-Enterprise Integration Laboratory Project (YQRH202501)

Shanghai Ninth People's Hospital Medical-Enterprise Integration Laboratory Project (YQRH202501)

Shanghai Ninth People's Hospital Medical-Enterprise Integration Laboratory Project (YQRH202501)

Shanghai Ninth People's Hospital Medical-Enterprise Integration Laboratory Project (YQRH202501)

Shanghai Ninth People's Hospital Medical-Enterprise Integration Laboratory Project (YQRH202501)

Shanghai Ninth People's Hospital Medical-Enterprise Integration Laboratory Project (YQRH202501)

Shanghai Science and Technology Innovation Action Plan (20Y11909600)

Shanghai Science and Technology Innovation Action Plan (20Y11909600)

Shanghai Science and Technology Innovation Action Plan (20Y11909600)

Shanghai Science and Technology Innovation Action Plan (20Y11909600)

Shanghai Science and Technology Innovation Action Plan (20Y11909600)

Shanghai Science and Technology Innovation Action Plan (20Y11909600)

Rare Disease Biobank Registration and Registry Project (JYHJB202404)

Rare Disease Biobank Registration and Registry Project (JYHJB202404)

Rare Disease Biobank Registration and Registry Project (JYHJB202404)

Rare Disease Biobank Registration and Registry Project (JYHJB202404)

Rare Disease Biobank Registration and Registry Project (JYHJB202404)

Rare Disease Biobank Registration and Registry Project (JYHJB202404)

Health Research Project of Anhui Province (AHWJ2024Aa20284,AHWJ2022A031)

Health Research Project of Anhui Province (AHWJ2024Aa20284,AHWJ2022A031)

Health Research Project of Anhui Province (AHWJ2024Aa20284,AHWJ2022A031)

Health Research Project of Anhui Province (AHWJ2024Aa20284,AHWJ2022A031)

Health Research Project of Anhui Province (AHWJ2024Aa20284,AHWJ2022A031)

Health Research Project of Anhui Province (AHWJ2024Aa20284,AHWJ2022A031)
License Information

Text and Data Mining valid from 2026-01-23

Version of Record valid from 2026-02-17
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Article History

Received: 6 October 2025

Accepted: 30 December 2025

First Online: 23 January 2026

Declarations

:

: UK Biobank has approval from the North West Multi-centre Research Ethics Committee (MREC) as a Research Tissue Bank (RTB) approval. All participants provided informed consent to participate. The present analyses were conducted under UK Biobank application number 88192.

: Not applicable.

: The authors declare no competing interests.

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