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Article History

Received: 3 January 2021

Accepted: 28 November 2021

First Online: 10 January 2022

Declarations

:

: The study was approved by the UK regulator (Medicines and Healthcare products Regulatory Agency, reference: 03057/0064/001–0001; Eudract 2015–000115–40) and national research ethics committee (IRAS: 167115) and was adopted by the National Institute for Health Research Clinical Research Network.Patients with capacity gave written informed consent to the attending paramedic, that covered the whole trial. If capacity was absent, proxy consent was obtained from an accompanying relative, carer, or friend, if present, or from the paramedic (with a witness) if no accompanying person was present. Confirmatory consent was obtained from the patient, or their relative, carer, or friend in hospital when the patient lacked capacity in the ambulance.

: Not applicable.

: PMB is Stroke Association Professor of Stroke Medicine and a National Institute for Health Research (NIHR) Senior Investigator. The views expressed in the article are those of the author(s) and do not necessarily represent those of NIHR or the Department of Health and Social Care. He reports grants from British Heart Foundation during the conduct of the study; personal fees and other fees from Sanofi, Nestlé, DiaMedica, Moleac, Platelet Solutions, Phagenesis, and ReNeuron, outside the submitted work. JMW was supported by the SFC SINAPSE Collaboration () and reports grants from the British Heart Foundation during the conduct of the study. NSp reports grants from British Heart Foundation, during the conduct of the study. TE reports grants from the British Heart Foundation during the conduct of the study. TR is an NIHR Senior Investigator. All other authors declare no competing interests.