Document is current

Article History

Received: 15 May 2018

Accepted: 14 January 2019

First Online: 23 January 2019

Ethics approval and consent to participate

: As previously reported, the two trials used in this study were registered with, numbers NCT02456740 and NCT02066415 [,]. For each of the study sites the final study protocol was approved by an Institutional Review Board/Independent Ethics Committee (IRB/IEC). The participants provided written informed consent before enrolment.

: Not applicable

: JP and GLDT are both Amgen employees.RBL is the Edwin S. Lowe Professor of Neurology at the Albert Einstein College of Medicine in New York. He receives research support from the NIH: 2PO1 AG003949 (Program Director), 5 U10 NS077308 (PI), 1RO1 AG042595 (Investigator), RO1 NS082432 (Investigator), K23 NS09610 (Mentor), K23AG049466 (Mentor). He also receives support from the Migraine Research Foundation and the National Headache Foundation. He serves on the editorial board of Neurology, is an associate editor of Cephalalgia, and as senior advisor to Headache. He has reviewed for the NIA and NINDS, holds stock options in eNeura Therapeutics and Biohaven Holdings; serves as consultant, advisory board member, or has received honoraria from: American Academy of Neurology, Alder, Allergan, American Headache Society, Amgen, Autonomic Technologies, Avanir, Biohaven, Biovision, Boston Scientific, Dr. Reddy’s, Electrocore, Eli Lilly, eNeura Therapeutics, GlaxoSmithKline, Merck, Pernix, Pfizer, Supernus, Teva, Trigemina, Vector, Vedanta. He receives royalties from Wolff’s Headache, 8th Edition, Oxford Press University, 2009, Wiley and Informa.AB has research grants from NIHR, PHE, NIH (US), and DH, and receives consulting fees from Amgen, GSK, RTI, TeamDRG.SP receives consulting fees from Amgen.SS and GV are employed by Amgen and have stock in Amgen.AJH was an employee of BresMed Health Solutions when the study was conducted, which received consulting fees from Amgen.

: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.