Document is current

Article History

Received: 12 December 2019

Accepted: 29 April 2020

First Online: 6 May 2020

Ethics approval and consent to participate

: The work has ethics committee approval from Norfolk Research Ethics Committee (Rec Ref: 98CN01) for EPIC-Norfolk baseline and later collections. The work was also approved by the East Norfolk and Waveney NHS research governance committee (2005EC07L) and the Norfolk research ethics committee (05/Q0101/191) for the EPIC-Norfolk Third Health Check collection. All participants gave informed signed consent for study participation including access to medical records.

: Not applicable.

: All authors have completed the ICMJE uniform disclosure form at and report: RL,SH,KTK and NW report grants from MRC and CRUK during the conduct of the study; The sponsors had no role in any of the following: study design, data collection, data analysis, interpretation of data, writing of the article, decision to submit it for publication. All authors are independent of funders and sponsors and had access to all the data. No conflicts of interest were declared by any author (apart from the two grants) and they have no other relationships or activities that could appear to have influenced the submitted work.