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Article History

Received: 21 February 2022

Accepted: 1 August 2022

First Online: 23 August 2022

Declarations

:

: The study protocol was approved by ethics committees at all participating institutions, and complies with the Declaration of Helsinki and Good Clinical Practice Guidelines. All patients signed a written informed consent to be enrolled. Methods were carried out in accordance with relevant national legal guidelines and regulations.Ethics approvals have been obtained by Ethics Committees in participating institutions as follows: Italian National Research Center on Aging (IRCCS INRCA), Italy, #2015 0522 IN, January 27, 2016. University of Lodz, Poland, #RNN/314/15/KE, November 17, 2015. Medizinische Universität Graz, Austria, #28–314 ex 15/16, August 5, 2016. Erasmus Medical Center Rotterdam, The Netherland, #MEC-2016–036—#NL56039.078.15, v.4, March 7, 2016. Hospital Clínico San Carlos, Madrid, Spain, # 15/532-E_BC, September 16, 2016. Bellvitge University Hospital Barcellona, Spain, #PR204/15, January 29, 2016. Friedrich-Alexander University Erlangen-Nürnberg, Germany, #340_15B, January 21, 2016. Helsinki committee in Maccabi Healthcare services, Bait Ba-lev, Bat Yam, Israel, #45/2016, July 24, 2016.

: Not applicable.

: EF, IM, RAM, PF, FL, AC, SB and RK declare no conflict of interest. The funder had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. EF is an editorial board member of BMC Geriatric.