Document is current

Article History

Received: 28 March 2023

Accepted: 30 June 2023

First Online: 14 July 2023

Declarations

:

: The study used anonymised data provided by the Clinical Practice Research Datalink (CPRD). CPRD has ethics approval from the NHS Health Research Authority to support research using anonymised patient data (East Midlands – Derby Research Ethics Committee, UK, reference 21/EM/0265). The need for informed consent for observational studies using anonymised CPRD data was waived by the East Midlands - Derby Research Ethics Committee (ref 21/EM/0265). Access to CPRD data is subject to protocol approval through CPRD’s Research Data Governance (RDG) Process, Medicines & Healthcare products Regulatory Agency, UK. The study protocol was approved by CPRD’s RDG in April 2022, and can be made available upon request (protocol number 22_001767). Patient consent is not required for GP practices to share data with CPRD, as no identifiable patient information is shared (ExternalRef removed). The research was performed in accordance with the Declaration of Helsinki, and with relevant guidelines and regulations.

: Not applicable.

: The authors declare support from the National Institute for Health and Care Research (NIHR) School for Primary Care Research (all), NIHR Nottingham Biomedical Research Centre (RMJ, RHJ, CACC), and NIHR MindTech MedTech Co-operative (DB, LW). AJA is National Clinical Director for Prescribing for NHS England. All other authors declare that they have no competing interests.