Osawa, Yusuke
Abe, Yukiko
Takayama, Michiyo
Arai, Yasumichi
Funding for this research was provided by:
Japan Society for the Promotion of Science (24K02711, 20590706)
the Japan Ministry of Agriculture, Forestry, and Fisheries
Foundation for Total Health Promotion
Chiyoda Mutual Life Foundation
Article History
Received: 25 February 2025
Accepted: 18 July 2025
First Online: 19 August 2025
Declarations
:
: The study protocol conformed to the principles of the Declaration of Helsinki, with approval of the ethics committees of the Keio University School of Medicine (No. 20070047), and written informed consent was obtained from all participants. The TOOTH study was registered in the University Hospital Medical Information Network Clinical Trial Registry under ID UMIN000001842 (4/10/2009).
: Not applicable.
: The authors declare no competing interests.