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Authors
Nagaoka, Ryohei https://orcid.org/0009-0002-0740-8677
Katano, Satoshi https://orcid.org/0000-0002-2562-1685
Yano, Toshiyuki https://orcid.org/0000-0001-9655-3985
Kawai, Makoto https://orcid.org/0000-0002-2372-9932
Adachi, Risa https://orcid.org/0009-0002-1302-5912
Nakata, Kei https://orcid.org/0000-0003-0747-7103
Habaguchi, Aki https://orcid.org/0009-0009-3186-522X
Yamano, Kotaro https://orcid.org/0009-0006-2637-2568
Ohori, Katsuhiko
Kouzu, Hidemichi https://orcid.org/0000-0001-7815-1464
Katayose, Masaki https://orcid.org/0000-0002-0483-8930
Furuhashi, Masato https://orcid.org/0000-0002-0145-3541
Taniguchi, Keigo https://orcid.org/0000-0003-1936-232X
Umemoto, Yasunori https://orcid.org/0000-0002-8005-9154
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Funding
Funding for this research was provided by:
Japan Society for the Promotion of Science (25K10715)
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Article History
Received: 10 January 2026
Accepted: 14 January 2026
First Online: 10 February 2026
Declarations
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: The study protocol was approved by the Institutional Review Board of Sapporo Medical University Hospital (Approval No. 372–40). The study is conducted in accordance with the Declaration of Helsinki and the Japanese Ethical Guidelines for Medical and Health Research Involving Human Subjects. Written informed consent will be obtained from all participants prior to enrollment. The study has been registered with the University Hospital Information Network (UMIN-CTR, identifier: UMIN000057756) on July 1, 2025.
: Not applicable. No individual person's data is contained.
: The authors declare no competing interests.
