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Authors
Esteban-Sepúlveda, Silvia https://orcid.org/0000-0002-0627-0680
Pascual-Garcia, Marcos https://orcid.org/0009-0000-1680-0289
Blanco, Joan https://orcid.org/0000-0002-4868-2974
Sánchez-Ruano, Raquel https://orcid.org/0000-0002-3642-162X
Cervera, Ana Mateo https://orcid.org/0000-0003-3537-1891
Moreno, Maria Angeles Cidoncha https://orcid.org/0000-0003-1844-9415
Vidal-Thomas, Maria-Clara https://orcid.org/0000-0002-9861-278X
Company-Sancho, María Consuelo https://orcid.org/0000-0002-5410-4791
Feria-Raposo, Isabel https://orcid.org/0000-0002-3119-4149
Casbas, Mayte Moreno https://orcid.org/0000-0001-9061-4628
Cameselle-Lago, Candela https://orcid.org/0000-0002-1326-799X
Artiques, Eva https://orcid.org/0000-0001-5756-696X
Padilla, Jorge https://orcid.org/0000-0001-8815-735X
Bernabéu, Clara https://orcid.org/0009-0009-7436-6690
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Esteban, Silvia
Moreno, Teresa
Abad, Eva
Ariztegui, Ana
Artigues, Eva
Avendaño, Almudena
Boixadera, Mireia
Cabeza, Antonio
Cameselle, Candela
Casado, Elvira
Cidoncha, MÁngeles
Company, Consuelo
Cortes, Elisa Belén
Etxebarria, Aitziber
Fabregat, Inmaculada
Feria, Isabel
Fernández, Roser
M, José Galán
García, Marta
Gimeno, Iraida
González, Víctor M.
Hernandez, Montserrat
Izaguirre, Eva
López, Yolanda
Losada, Antonio
Lozano, Cristina
Martín, Ángel
Martín, Susana
Más, Marta
Mateo, Ana
Miralles, Jerónima
Moreno, Maribel Noel
Oter, Cristina
Otones, Pedro
Padilla, Jorge Rafael
Palmar, Ana M.
Pastor, Monica
Pedraz, Azucena
Pisà, Marta
Reina, Gloria
Rich, Manuel
Romero, Esperanza M.
Ruymán, Pedro
Sarabia, Carmen M.
Solé, María
Taltavull, Joana Maria
Vicente, Sergio
Vidal, Clara
Céspedes, Almudena Avendaño
Zamora, Elisa Belén Cortés
Alsina, Gemma Hidalgo
Fitó, Marta Puig
Badia, Maria Rosa Rami
Aguilar, Maria Eugènia Obis
Bueria, Anna Guiu
Morales, Maria Teresa Palau
Julvé, Inmaculada Fabregat
Aicart, Clara Bernabeu
Tena, Juan Miguel Mestre
Brea, Marta Tomas
Membrado, María Dolores Parreño
Escuder, Carla Gimeno
Monedero, Ana Moliner
Pérez, Alberto Cano
Arroyo, Anunciación Martínez
Ramos, Carmen Luzdivina Sánchez
Ramírez, Carolina Regacho
Sierra, Consuelo Carretero
Sanz, Cristina Villanueva
Romero, David Verdagay
García, Diego Ruiz
García, Elena Monteagudo
Barra, Elena Rojas
Sancho, Elvira Herrero
Espejo, Esther Luna
Rodríguez, Gema Díez
Vera, Gloria Leyva
Pozo, Gonzalo Nuevo
Redondo, Ines Melero
García-Herrera, Inmaculada Moreno
González, Isabel Careaga
Cuadra, Laura Villanova
Ruiz, Lorena Ríos
Galindo, Luis Huerta
López, María Ángeles Almodovar
de Luna, María Concepción Hernández
Montero, María Isabel Adillo
Martín, María Jesús Santamaría
Molina, María Luisa Romero
Moreno, Nadia Kamal
Calleja, Paloma Garrido
Obesso, Pedro Vadillo
Zarza, Raquel López
Rincón, Raquel Razola
Sánchez, Rocío López
Márquez, Samuel Lobato
Jorge, Sara Criado
de la Cuadra, Silvia Morcillo
Barbero, Teresa Susmozas Rodríguez
Ibáñez, Ana María Carpio
de Cadiñanos, Elena García Gómez
Sancho, Maria Consuelo Company
Sánchez, Rita Mendoza
Delgado, María José García
Monzón Monzón, Guillermo
Díaz Díaz, Maria Isabel
Hernández, María Dolores Suárez
Angulo, Beatriz Candela
Andrade, Maria Paula Martín
Araujo, Pedro Jorge
Aguiar, Eduardo Santana
Montesdeoca, Sandra Morales
Martín, Laura Figueroa
Luis, Haridian Galdona
Mata, Silvia Martínez
Tirado, Rosa Mellado
Suárez, Irene Parrilla
Santana, Sara Ramos
Delgado, Victoria Plasencia
Hernández, Ingrid Rodríguez
Maestre, Jorge Rafael Padilla
Bollo, Sergio Garrido
de la Torre, Teresa Martínez
Castilla, Inmaculada Guzmán
Cadena, María Artieda
Urtiaga, Vanesa Ayesa
Erro, Itziar Berasain
Beorlegui, Anamaría Zubillaga
Razquin, Graciela Ilundain
Pardo, María Carmen Gutiérrez
Matinez, Maite Lucea
Villanueva, Mónica Magno
de Leyre Martínez Zaborras, María
Cabodevilla, María Jesús Martínez
Espinilla, María José Galán
Echenique, Ana María Ariztegui
Leal, Maribel Moreno
Lejarreta, Ana Isabel Barrenetxea
Soto, Asier Albestegi
Domínguez, María Félix Iglesias
Alcalá, Ruth Gallo
Alfonso, Elisabet Carrera
Gaia, Mara Pisà
Xamena, Jerónima Miralles
Jiménez, Milagros Sánchez
Mestre, M. Josep Barea
Salom, Elena García
Duran, Nuria Garcia
Burguera, Rosa María Pons
Severi, Wiliam Andres
Bermejo, Tamara Góméz
Guerrero, Ana Belén Campos
Fuster, Marta Perelló
Yeste, M. Soledad Hernandez
Rodriguez, Elena Terrón
Rico-Blázquez, Milagros https://orcid.org/0000-0001-7308-4450
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Funding
Funding for this research was provided by:
Instituto de Salud Carlos III (PI21/00648)
Instituto de Salud Carlos III (PI21CIII/00015)
Instituto de Salud Carlos III (PI21/00190)
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Article History
Received: 21 February 2026
Accepted: 20 July 2026
First Online: 7 August 2026
Declarations
Ethics approval and consent to participate: The study involving humans was approved by the Central Research Commission of Primary Healthcare Management of the Madrid Health Service and by the Ethics Committee for Drugs Research (CEIm) of University Hospital La Princesa in June 2022. All participating regions obtained approval from their respective research ethics committees. The study was conducted in accordance with the applicable ethical and legal requirements, including the principles of the Declaration of Helsinki (2024), the Oviedo Convention on Human Rights and Biomedicine, Regulation (EU) 2016/679 (General Data Protection Regulation), and Spanish Organic Law 3/2018 on Personal Data Protection and the guarantee of digital rights. All participants provided written informed consent before inclusion. Study data were collected and managed using standardized electronic case report forms implemented in REDCap®. Access to the database was restricted to authorized members of the research team through individual user credentials. The analytical database did not include directly identifiable personal information.
Consent for publication: Not Applicable. All data are presented in aggregated form and no identifying images or personal or clinical details of participants are included in this manuscript.
Competing interests: The authors declare no competing interests.
