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Authors
Fu, Liang
Shi, Huaifang
Sun, Feng
Wang, Wenfei
Zhang, Peize
Yang, Qianting
Cai, Yi
Zhang, Xilin
Liang, Hancheng
Wang, Zhaoqing
Xiong, Juan
Chen, Xinchun
Zhang, Wenhong
Deng, Guofang
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Funding
Funding for this research was provided by:
Science, Technology and Innovation Commission of Shenzhen Municipality (KCXFZ20211020163811027)
National Key Research and Development Program of China (2023YFC2307200)
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Article History
Received: 15 November 2025
Accepted: 9 January 2026
First Online: 24 February 2026
Declarations
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: The study was conducted in accordance with the Declaration of Helsinki and Good Clinical Practice (GCP) guidelines. The study was approved by institutional review boards at participating centres, and all participants provided written informed consent. The study is registered at ChiCTR2000032298 on April 25, 2020.
: Not applicable.
: During the preparation of this work, the authors used ChatGPT and DeepSeek for language refinement and statistical code writing. No AI was used to generate any original data. After using these tools, all authors reviewed and edited the content as needed and take full responsibility for the content of the publication.
: The authors declare no competing interests.
