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Efficacy and safety of levornidazole disodium phosphate injection in patients with intra-abdominal infections caused by anaerobic bacteria: a multicenter, randomized, single-blind, phase IV, non-inferiority trial (ANAEROGUARD study)

Crossref DOI link: https://doi.org/10.1186/s12879-026-12789-7

Published Online: 2026-02-28

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Chen, Lin

Zhang, Lei

Chen, Rufu

Zheng, Zhiwei

Zhou, Li

Zhu, Xiufang

Wang, Yuanyuan

Ni, Desheng

Chen, Xiang

Zhao, Shuguang

Zhou, Yuhuai

Shao, Chuxiao

Xu, Jian

Sun, Feng

Wang, Guoying

Zhao, Tao

Li, Xiaorong

Wang, Quan

Liu, Shuanghai

Cao, Jiaqing

Fu, Yang

Ye, Jianxin

Wang, Bin

Ding, Youming

Wang, Wei

Zhang, Yunjie

Huang, Bo

Huang, Jianzhao

Han, Wei

Guan, Wenxian

Zhang, Jialin

Zhang, Zhongtao

Yu, Jiren

Yang, Jiaojiao

Lan, Yong

Chen, Xiaoping
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Text and Data Mining valid from 2026-02-28

Version of Record valid from 2026-04-07
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Article History

Received: 23 December 2025

Accepted: 2 February 2026

First Online: 28 February 2026

Declarations

:

: The study was conducted in accordance with the Declaration of Helsinki and the International Council for Harmonisation’s Good Clinical Practice guidelines. Approval was obtained from the medical ethics committees of each participating center. All patients provided written informed consent.

: Not applicable.

: The authors declare no competing interests.

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